The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics.
作者信息
Moghimi Ali, Mollazadeh Samaneh, Rassouli Fatemeh Behnam, Shiee Reza, Khalilzade Mohammad Ali
机构信息
The Applied Research Center for Neurofeedback and Neurobehavioral Sciences (Aren), Ferdowsi University of Mashhad, Iran.
Biotechnology Research Center, Bu-Ali Research Institute, Mashhad University of Medical Science, Mashhad, Iran.
出版信息
Basic Clin Neurosci. 2013 Winter;4(1):31-5.
INTRODUCTION
Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects.
METHODS
For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others.
RESULTS
Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups.
DISCUSSION
These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.
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