Xu Chun-Jin, Xu Feng
Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan, China ; Department of Gastroenterology, The First People's Hospital of Shangqiu City Shangqiu, Henan, China.
Department of Gastroenterology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan, China.
Int J Clin Exp Med. 2014 Sep 15;7(9):2883-8. eCollection 2014.
Colorectal cancer is one of the most common types of cancer and has a high mortality rate, making accurate prediction of clinical prognosis an important concern. This study sought to investigate the expression of two proteins, MMP-11 and VEGF-C, in colorectal adenocarcinoma tissues to provide options for better tumor detection. The correlation of the expression of these proteins with the clinical and pathological features of colorectal adenocarcinoma and with the invasion and metastasis of colorectal adenocarcinoma were assessed. Immunohistochemistry with light microscopy was used to detect the expression level of MMP-11 and VEGF-C in 78 samples of colorectal adenocarcinoma tissues and in 20 samples of normal colorectal tissues. Expression of MMP-11 in colorectal adenocarcinoma tissues and normal colorectal tissues was detected in 55.1% and 30.0% of samples, respectively; VEGF-C was detected in 78.2% and 15.0% of samples, respectively. The expression of MMP-11 and VEGF-C in colorectal adenocarcinoma tissues were not related to patient age, sex, or tumor location. However, expression was related to Dukes' staging and lymph node metastasis. Expression of MMP-11 was correlated with distant metastasis from tumors. Lastly, expression of MMP-11 in colorectal adenocarcinoma was positively correlated with VEGF-C. In brief, expression of MMP-11 and VEGF-C in colorectal adenocarcinoma tissues serves as a significant index for evaluating the degree of malignancy, clinical stages, lymph nodes, and distant metastasis of colorectal adenocarcinoma. The detection of both of these proteins may help predict the infiltration, metastasis, and prognosis of colorectal adenocarcinoma, and potentially offers new targets for clinical treatment.
结直肠癌是最常见的癌症类型之一，死亡率很高，因此准确预测临床预后是一个重要问题。本研究旨在调查两种蛋白MMP-11和VEGF-C在结直肠腺癌组织中的表达，为更好地进行肿瘤检测提供选择。评估了这些蛋白的表达与结直肠腺癌临床病理特征以及与结直肠腺癌侵袭和转移的相关性。采用免疫组织化学结合光学显微镜检测78例结直肠腺癌组织样本和20例正常结直肠组织样本中MMP-11和VEGF-C的表达水平。MMP-11在结直肠腺癌组织和正常结直肠组织样本中的表达检出率分别为55.1%和30.0%；VEGF-C的检出率分别为78.2%和15.0%。MMP-11和VEGF-C在结直肠腺癌组织中的表达与患者年龄、性别或肿瘤位置无关。然而，表达与Dukes分期和淋巴结转移有关。MMP-11的表达与肿瘤远处转移相关。最后，结直肠腺癌中MMP-11的表达与VEGF-C呈正相关。简而言之，MMP-11和VEGF-C在结直肠腺癌组织中的表达是评估结直肠腺癌恶性程度、临床分期、淋巴结及远处转移的重要指标。检测这两种蛋白可能有助于预测结直肠腺癌的浸润、转移和预后，并可能为临床治疗提供新的靶点。
