Ullah Ghafoor, Noor Sahibzada Mehmood, Bhatti Zubair, Ahmad Munir, Bangash Abdur Rahim
J Ayub Med Coll Abbottabad. 2014 Jan-Mar;26(1):64-7.
Acne vulgaris is a common inflammatory disorder of the skin that involves pilosebaceous units. This study was conducted to compare the efficacy of oral azithromycin with oral doxycycline in the treatment of acne vulgaris in our population.
This randomized controlled trial was conducted in the dermatology department of Lady Reading Hospital, Peshawar from January to December 2011. All male and female patients of age (14-30 years) having moderate acne vulgaris on face only were included in the study. Patients were randomly divided into two groups. Patients in first group were given azithromycin 500 mg daily before meal for 4 consecutive days monthly for 3 months while patients in second group were given doxycycline 100 mg daily after meals for 3 months. Patients were followed up after taking treatment for three months to see the response of each drug. Response was graded as excellent, good, moderate, mild and no response.
A total of 386 patients equally divided in azithromycin and doxycycline groups. Male to female ratio in azithromycin and doxycycline groups was 0.82:1.11 and 0.89:1.04 respectively. Mean age in both groups was 18.45 ± 2.91 years and 17.96 ± 2.59 years respectively. In azithromycin group, an excellent response was noted in 6 (3.1%), and good response was observed in 44 (22.8%) patients. In doxycycline group 22 (11.4%) patients had excellent and 107 (55.4%) patients had good response. The difference being statistically significant.
Doxycycline is a better option fdr treatment of acne vulgaris as compared to azithromycin.
寻常痤疮是一种常见的累及毛囊皮脂腺单位的皮肤炎症性疾病。本研究旨在比较口服阿奇霉素与口服多西环素治疗我国人群寻常痤疮的疗效。
本随机对照试验于2011年1月至12月在白沙瓦市雷丁夫人医院皮肤科进行。纳入所有年龄在14至30岁之间、仅面部患有中度寻常痤疮的男性和女性患者。患者被随机分为两组。第一组患者每月连续4天每天饭前服用500毫克阿奇霉素，共3个月；而第二组患者每天饭后服用100毫克多西环素，共3个月。治疗3个月后对患者进行随访，观察每种药物的疗效。疗效分为优、良、中、差和无效。
共有386例患者被平均分为阿奇霉素组和多西环素组。阿奇霉素组和多西环素组的男女比例分别为0.82:1.11和0.89:1.04。两组的平均年龄分别为18.45±2.91岁和17.96±2.59岁。在阿奇霉素组中，6例（3.1%）患者疗效为优，44例（22.8%）患者疗效为良。在多西环素组中，22例（11.4%）患者疗效为优，107例（55.4%）患者疗效为良。差异具有统计学意义。
与阿奇霉素相比，多西环素是治疗寻常痤疮的更好选择。
