脐带血脂肪因子与新生儿体重变化

Umbilical cord blood adipokines and newborn weight change.

作者信息

Fonseca Maria João, Santos Ana Cristina

机构信息

Department of Clinical Epidemiology, Predictive Medicine and Public Health, University of Porto Medical School, Porto, Portugal,

出版信息

Arch Gynecol Obstet. 2015 May;291(5):1037-40. doi: 10.1007/s00404-014-3534-8. Epub 2014 Nov 11.

DOI:10.1007/s00404-014-3534-8

PMID:25384519

Abstract

PURPOSE

To ascertain the association between umbilical cord levels of adiponectin, leptin and resistin, and birth weight (BW) and newborn weight change (NWC) in the first 96 h of life.

METHODS

392 full-term singletons were recruited, in 2005/2006, at the five public units providing obstetrical and neonatal care in Porto. Information was collected by face-to-face interview and additionally from clinical records. Umbilical cord blood adipokines levels were determined and categorized using the 10th and 90th percentiles. Anthropometrics were obtained by trained examiners and NWC estimated as (weight - BW)/BW × 100, adjusted for newborn's age. Regression coefficients and 95% confidence intervals were calculated.

RESULTS

Low leptin levels (≤5.6 ng/ml) were associated with lower BW (β = -137.3 g 95%CI -268.6 g, -6.1 g) and high leptin levels (≥30.7 ng/ml) were associated with higher BW (β = 276.3 g 95%CI 145.8 g, 406.8 g) and higher NWC (β = 1.10% 95% CI 0.29%, 1.92%), comparing to newborns with normal leptin levels. Adiponectin and resistin were not associated with BW or NWC.

CONCLUSION

High umbilical cord blood leptin levels predicted higher BW and lower weight loss in the immediate postnatal period.

摘要

目的

确定脐血中脂联素、瘦素和抵抗素水平与出生体重（BW）以及出生后96小时内新生儿体重变化（NWC）之间的关联。

方法

2005/2006年，在波尔图提供产科和新生儿护理的五个公共单位招募了392名单胎足月儿。通过面对面访谈收集信息，并从临床记录中获取额外信息。测定脐血脂肪因子水平，并使用第10和第90百分位数进行分类。由经过培训的检查人员进行人体测量，并将NWC估计为（体重 - BW）/BW×100，并根据新生儿年龄进行调整。计算回归系数和95%置信区间。

结果

与瘦素水平正常的新生儿相比，低瘦素水平（≤5.6 ng/ml）与较低的BW相关（β = -137.3 g，95%CI -268.6 g，-6.1 g），高瘦素水平（≥30.7 ng/ml）与较高的BW相关（β = 276.3 g，95%CI 145.8 g，406.8 g）以及较高的NWC相关（β = 1.10%，95%CI 0.29%，1.92%）。脂联素和抵抗素与BW或NWC无关。