美国两例埃博拉病毒病患者的临床护理。

Clinical care of two patients with Ebola virus disease in the United States.

机构信息

From the Departments of Medicine (G.M.L., A.K. Mehta, J.B.V., C.S.K., B.S.R.), Pathology (C.S.K.), and Pediatrics (A.K. McElroy), Division of Infectious Diseases, Emory University School of Medicine, and the Centers for Disease Control and Prevention (A.K. McElroy, J.S.T., C.S., U.S., T.M.U.) - both in Atlanta; and Samaritan's Purse, Boone, NC (K.B., L.P.).

出版信息

N Engl J Med. 2014 Dec 18;371(25):2402-9. doi: 10.1056/NEJMoa1409838. Epub 2014 Nov 12.

DOI:10.1056/NEJMoa1409838

PMID:25390460

Abstract

West Africa is currently experiencing the largest outbreak of Ebola virus disease (EVD) in history. Two patients with EVD were transferred from Liberia to our hospital in the United States for ongoing care. Malaria had also been diagnosed in one patient, who was treated for it early in the course of EVD. The two patients had substantial intravascular volume depletion and marked electrolyte abnormalities. We undertook aggressive supportive measures of hydration (typically, 3 to 5 liters of intravenous fluids per day early in the course of care) and electrolyte correction. As the patients' condition improved clinically, there was a concomitant decline in the amount of virus detected in plasma.

摘要

目前，西非正在经历有史以来最大规模的埃博拉病毒病（EVD）疫情爆发。两名埃博拉病毒病患者从利比里亚被转送至我们在美国的医院进行后续治疗。其中一名患者还被诊断患有疟疾，并在埃博拉病毒病发病早期就接受了治疗。这两名患者存在大量的血管内容量不足和明显的电解质异常。我们采取了积极的支持性治疗措施，包括水化（通常在开始治疗的早期每天静脉补液 3 至 5 升）和电解质纠正。随着患者临床状况的改善，血浆中检测到的病毒量也随之下降。