Maruani Antoine, Alom Shamim, Canavelli Pierre, Lee Maximillian T W, Morgan Rachel E, Chudasama Vijay, Caddick Stephen
Department of Chemistry, University College London, 20 Gordon Street, London, WC1H OAJ, UK.
Chem Commun (Camb). 2015 Mar 28;51(25):5279-82. doi: 10.1039/c4cc08515a.
It has recently emerged that the succinimide linkage of a maleimide thiol addition product is fragile, which is a major issue in fields where thiol functionalisation needs to be robust. Herein we deliver a strategy that generates selective cysteine thiol labelling reagents, which are stable to hydrolysis and thiol exchange.
最近发现，马来酰亚胺硫醇加成产物的琥珀酰亚胺键很脆弱，这在需要硫醇功能化稳定的领域是一个主要问题。在此，我们提供了一种策略，可生成对水解和硫醇交换稳定的选择性半胱氨酸硫醇标记试剂。
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