Adamowicz Piotr, Zuba Dariusz
Institute of Forensic Research, Westerplatte 9, Krakow, 31-033, Poland.
J Forensic Sci. 2015 Jan;60 Suppl 1:S264-8. doi: 10.1111/1556-4029.12594. Epub 2014 Nov 20.
Methoxetamine (MXE) is a new synthetic drug of abuse structurally related to ketamine and phencyclidine. A case of a 29-year-old male with acute toxicity related to the analytically confirmed use of MXE is reported. The man was found dead at his residence. Biological material was analyzed using liquid chromatography-tandem mass spectrometry. The concentration of MXE in urine of the deceased was 85 μg/mL. Despite the vial containing the blood sample being destroyed during transportation and the blood leaking out into the cardboard packaging, the blood level of MXE was estimated. After determination of the cardboard grammage (approx. 400 g/m(3) ) and the mean mass of the blood obtained after drying (0.1785 ± 0.0173 g per 1 mL), the estimated blood concentration of MXE was found to be 5.8 μg/mL. The high concentration of MXE in blood and urine and the circumstances of the case indicate an unintentional, fatal intoxication with this substance.
甲氧基苯环利定（MXE）是一种新型合成滥用药物，在结构上与氯胺酮和苯环己哌啶有关。本文报告了一例29岁男性因经分析确认使用MXE而导致急性中毒的病例。该男子被发现死于家中。使用液相色谱 - 串联质谱法对生物材料进行了分析。死者尿液中甲氧基苯环利定的浓度为85μg/mL。尽管装有血样的小瓶在运输过程中被损坏，血液泄漏到硬纸板包装中，但仍对甲氧基苯环利定的血液浓度进行了估算。在测定硬纸板克重（约400 g/m³）和干燥后获得的血液平均质量（每1 mL为0.1785±0.0173 g）后，估算出甲氧基苯环利定的血液浓度为5.8μg/mL。血液和尿液中甲氧基苯环利定的高浓度以及该病例的情况表明该物质导致了意外的致命中毒。
