Benson Dennis A, Clark Karen, Karsch-Mizrachi Ilene, Lipman David J, Ostell James, Sayers Eric W
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA
Nucleic Acids Res. 2015 Jan;43(Database issue):D30-5. doi: 10.1093/nar/gku1216. Epub 2014 Nov 20.
GenBank(®) (http://www.ncbi.nlm.nih.gov/genbank/) is a comprehensive database that contains publicly available nucleotide sequences for over 300 000 formally described species. These sequences are obtained primarily through submissions from individual laboratories and batch submissions from large-scale sequencing projects, including whole-genome shotgun and environmental sampling projects. Most submissions are made using the web-based BankIt or standalone Sequin programs, and GenBank staff assign accession numbers upon data receipt. Daily data exchange with the European Nucleotide Archive and the DNA Data Bank of Japan ensures worldwide coverage. GenBank is accessible through the NCBI Entrez retrieval system, which integrates data from the major DNA and protein sequence databases along with taxonomy, genome, mapping, protein structure and domain information, and the biomedical journal literature via PubMed. BLAST provides sequence similarity searches of GenBank and other sequence databases. Complete bimonthly releases and daily updates of the GenBank database are available by FTP.
GenBank(®)(http://www.ncbi.nlm.nih.gov/genbank/)是一个综合性数据库,包含超过30万个正式描述物种的公开可用核苷酸序列。这些序列主要通过各个实验室的提交以及大规模测序项目(包括全基因组鸟枪法测序和环境采样项目)的批量提交获得。大多数提交是使用基于网络的BankIt程序或独立的Sequin程序进行的,GenBank工作人员在收到数据时会分配登录号。与欧洲核苷酸档案馆和日本DNA数据库的每日数据交换确保了全球范围的覆盖。GenBank可通过NCBI Entrez检索系统访问,该系统整合了来自主要DNA和蛋白质序列数据库的数据,以及分类学、基因组、图谱、蛋白质结构和结构域信息,还有通过PubMed获取的生物医学期刊文献。BLAST可对GenBank和其他序列数据库进行序列相似性搜索。GenBank数据库每两个月进行一次完整发布,并通过FTP进行每日更新。