Mrejen Sarah, Pang Claudine E, Sarraf David, Goldberg Naomi R, Gallego-Pinazo Roberto, Klancnik James M, Sorenson John A, Yannuzzi Lawrence A, Freund K Bailey
Ophthalmic Surg Lasers Imaging Retina. 2014 Nov-Dec;45(6):562-9. doi: 10.3928/23258160-20141118-12.
To assess the cone photoreceptor mosaic in acute macular neuroretinopathy (AMN) using adaptive optics (AO) imaging.
Four patients with AMN were evaluated retrospectively by near-infrared reflectance (IR) confocal scanning laser ophthalmoscopy (SLO), spectral-domain optical coherence tomography (SD-OCT), and a flood-illuminated retinal AO camera. Microperimetry was performed in one patient.
The cone photoreceptor density was decreased at the level of the AMN lesions. The cone mosaic disruption appeared heterogeneous and more widespread than the lesion detected in the IR-SLO and SD-OCT images. The areas of cone loss correlated with SD-OCT and microperimetry. After resolution of the AMN lesion on IR-SLO, there was incomplete recovery of the cone photoreceptor mosaic.
Cone photoreceptor damage and reconstitution were documented in vivo at the cellular level in AMN using AO imaging. AO imaging appeared more sensitive than combined IR-SLO and SD-OCT to detect and follow photoreceptor damage in patients with AMN.
使用自适应光学（AO）成像评估急性黄斑神经视网膜病变（AMN）中的视锥光感受器镶嵌。
对4例AMN患者进行回顾性评估，采用近红外反射（IR）共焦扫描激光眼科显微镜检查（SLO）、光谱域光学相干断层扫描（SD - OCT）以及泛光照明视网膜AO相机。对1例患者进行了微视野检查。
在AMN病变水平处，视锥光感受器密度降低。视锥镶嵌破坏表现为异质性，且比IR - SLO和SD - OCT图像中检测到的病变更广泛。视锥细胞丢失区域与SD - OCT及微视野检查结果相关。IR - SLO上AMN病变消退后，视锥光感受器镶嵌未完全恢复。
使用AO成像在体内细胞水平记录了AMN中视锥光感受器的损伤与重建。在检测和跟踪AMN患者的光感受器损伤方面，AO成像似乎比联合使用IR - SLO和SD - OCT更敏感。
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