Reuter Suzanne, Messier Stephen, Steven Dennis
S D Med. 2014 Oct;67(10):397-403, 405.
The "Golden Hour," the first 60 minutes following the birth of an extremely premature infant, are perhaps the most important of his or her life. Specific attention to respiratory management, temperature regulation, and vascular access, undertaken via a standardized approach may have immeasurable long-term benefits, and make the difference between life and death.
We present our new approach to the extremely premature infant during the Golden Hour, a protocol to improve the initial body temperature, length of hospital stay, and incidence of bronchopulmonary dysplasia of the extremely low birth weight infant.
We did not find statistically significant differences in minimum temperature during resuscitation, length of hospital stay or rate of bronchopulmonary dysplasia after implementation of the Golden Hour. We observed a decrease in the incidence of intraventricular hemorrhage (IVH) (18 versus 46 percent). The placement of umbilical catheters was much faster during the Golden Hour (35 versus 56 minutes) but arrival in the NICU was significantly delayed (80 versus 15 minutes).
We were not able to detect differences in temperature management, bronchopulmonary dysplasia or average length of hospital stay following implementation of the Golden Hour protocol. However, we observed a marked decrease in intraventricular hemorrhage and faster time for umbilical catheter insertion than prior to the protocol. Long-term follow-up of these infants is critical to assess neurodevelopmental benefits gained from use of the protocol.
“黄金一小时”,即极早产儿出生后的最初60分钟,可能是其一生中最重要的时段。通过标准化方法对呼吸管理、体温调节和血管通路给予特别关注,可能会带来不可估量的长期益处,并决定生死。
我们介绍了在“黄金一小时”期间针对极早产儿的新方法,这是一项旨在提高极低出生体重儿初始体温、住院时间以及支气管肺发育不良发生率的方案。
在实施“黄金一小时”方案后,我们未发现复苏期间最低体温、住院时间或支气管肺发育不良发生率存在统计学上的显著差异。我们观察到脑室内出血(IVH)的发生率有所下降(从46%降至18%)。在“黄金一小时”期间,脐静脉导管的放置速度要快得多(35分钟对56分钟),但到达新生儿重症监护病房(NICU)的时间显著延迟(80分钟对15分钟)。
在实施“黄金一小时”方案后,我们未能检测到体温管理、支气管肺发育不良或平均住院时间方面的差异。然而,我们观察到脑室内出血明显减少,且脐静脉导管插入时间比该方案实施前更快。对这些婴儿进行长期随访对于评估该方案带来的神经发育益处至关重要。