Rsp5/Nedd4 清除受热损伤蛋白的细胞。
Rsp5/Nedd4 clears cells of heat-damaged proteins.
机构信息
Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, D-13125 Berlin, Germany.
出版信息
Nat Cell Biol. 2014 Dec;16(12):1130-2. doi: 10.1038/ncb3079.
DOI:10.1038/ncb3079
PMID:25434464
Abstract
Protein quality control systems protect cells from proteotoxicity caused by the accumulation of aberrantly folded polypeptides. The Rsp5 ubiquitin ligase (mammalian homologue Nedd4) is now identified as a major constituent of a clearance pathway that degrades misfolded cytosolic proteins after exposure to heat.
摘要
蛋白质质量控制系统可保护细胞免受异常折叠多肽积累引起的毒性。Rsp5 泛素连接酶（哺乳动物同源物 Nedd4）现在被确定为一种清除途径的主要组成部分，该途径可在暴露于热后降解错误折叠的胞质蛋白。
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