低剂量双酚A暴露会损害青春期前大鼠的垂体-卵巢轴：对早期卵泡发生的影响。
Exposure to a low dose of bisphenol A impairs pituitary-ovarian axis in prepubertal rats: effects on early folliculogenesis.
作者信息
Gámez J M, Penalba R, Cardoso N, Bernasconi P Scacchi, Carbone S, Ponzo O, Pandolfi M, Scacchi P, Reynoso R
机构信息
Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina.
Laboratory of Endocrinology, Department of Physiology, Faculty of Medicine, University of Buenos Aires, Buenos Aires, Argentina; Department of Teaching and Research, Faculty of Medical Sciences, Pontificia Universidad Católica, Católica, Argentina.
出版信息
Environ Toxicol Pharmacol. 2015 Jan;39(1):9-15. doi: 10.1016/j.etap.2014.10.015. Epub 2014 Nov 4.
The research work studies the effect of providing a low dose of bisphenol A (BPA), on the reproductive axis of prepubertal female rats. Wistar mated rats were treated with either 0.1% ethanol or BPA in their drinking water until their offspring were weaned on the 21 day of birth. The estimated average dose of exposure to dams was approximately 3μg/kg/day. The pups were sacrificed at the 30th day of life. Body weight at the moment of the sacrifice was significantly higher in the group exposed to BPA; ovarian weight and its relative weight were not modified. LH and estradiol levels increased significantly, meanwhile FSH ones showed no significant changes. The number of primary, secondary and atretic follicles increased and antral ones was decreased. Our results demonstrated that early exposure to a low dose of BPA disrupts the normal function of the reproductive axis in prepubertal female rats.
该研究工作探讨了低剂量双酚A（BPA）对青春期前雌性大鼠生殖轴的影响。将Wistar交配后的大鼠用0.1%乙醇或饮用水中的BPA处理，直至其后代在出生后第21天断奶。估计母鼠的平均暴露剂量约为3μg/kg/天。幼崽在出生后第30天处死。处死时，暴露于BPA组的体重显著更高；卵巢重量及其相对重量未改变。促黄体生成素（LH）和雌二醇水平显著升高，而促卵泡生成素（FSH）水平无显著变化。初级、次级和闭锁卵泡数量增加，而窦状卵泡数量减少。我们的结果表明，早期暴露于低剂量BPA会扰乱青春期前雌性大鼠生殖轴的正常功能。
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