经化疗后病理完全缓解的胆管癌患者：探讨新辅助治疗在胆道癌中的作用。
A patient with cholangiocarcinoma demonstrating pathologic complete response to chemotherapy: exploring the role of neoadjuvant therapy in biliary tract cancer.
机构信息
1 Division of Hematology/Oncology, 2 Departments of Anatomic Pathology, Urology and Radiation Oncology, 3 Department of Surgery, University of California, San Francisco, USA.
出版信息
J Gastrointest Oncol. 2014 Dec;5(6):E88-95. doi: 10.3978/j.issn.2078-6891.2014.051.
Abstract
The role of neoadjuvant chemotherapy and/or radiation for localized or potentially resectable cholangiocarcinoma (CCA) has not been well established. We present here the case of a patient with an extrahepatic CCA who achieved a pathologic complete response after undergoing preoperative gemcitabine-based chemotherapy, without sequential or concurrent use of radiation. Further evaluation of neoadjuvant strategies in CCA, including not only combined-modality therapy but also the use of chemotherapy exclusively, is warranted in prospective study design.
摘要
局部或潜在可切除的胆管癌（CCA）的新辅助化疗和/或放疗的作用尚未得到充分确立。我们在此介绍了一例肝外 CCA 患者，该患者在接受术前基于吉西他滨的化疗后获得了病理完全缓解，且未序贯或同时使用放疗。前瞻性研究设计需要进一步评估 CCA 的新辅助策略，包括不仅联合治疗模式，还包括单独使用化疗。
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本文引用的文献
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2
Neoadjuvant therapy for downstaging of locally advanced hilar cholangiocarcinoma: a systematic review.
HPB (Oxford). 2014 Apr;16(4):297-303. doi: 10.1111/hpb.12150. Epub 2013 Aug 26.
3
Yttrium-90 radioembolization for intrahepatic cholangiocarcinoma: safety, response, and survival analysis.
J Vasc Interv Radiol. 2013 Aug;24(8):1227-34. doi: 10.1016/j.jvir.2013.02.031. Epub 2013 Apr 19.
4
Neoadjuvant chemoradiotherapy followed by liver transplantation for unresectable cholangiocarcinoma: a single-centre national experience.
HPB (Oxford). 2014 Jan;16(1):91-8. doi: 10.1111/hpb.12082. Epub 2013 Apr 18.
5
Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies.
Oncogene. 2013 Oct 10;32(41):4861-70. doi: 10.1038/onc.2012.617. Epub 2013 Jan 14.
6
Surgical resection after downsizing chemotherapy for initially unresectable locally advanced biliary tract cancer: a retrospective single-center study.
Ann Surg Oncol. 2013 Jan;20(1):318-24. doi: 10.1245/s10434-012-2312-8. Epub 2012 Nov 13.
7
Effect of adjuvant chemotherapy with fluorouracil plus folinic acid or gemcitabine vs observation on survival in patients with resected periampullary adenocarcinoma: the ESPAC-3 periampullary cancer randomized trial.
JAMA. 2012 Jul 11;308(2):147-56. doi: 10.1001/jama.2012.7352.
8
Neither neoadjuvant nor adjuvant therapy increases survival after biliary tract cancer resection with wide negative margins.
J Gastrointest Surg. 2012 Sep;16(9):1666-71. doi: 10.1007/s11605-012-1935-1. Epub 2012 Jul 10.
9
Adjuvant therapy in the treatment of biliary tract cancer: a systematic review and meta-analysis.
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Efficacy of neoadjuvant chemoradiation, followed by liver transplantation, for perihilar cholangiocarcinoma at 12 US centers.
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