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[中间葡萄膜炎的治疗]

[Therapy of intermediate uveitis].

作者信息

Doycheva D, Deuter C, Zierhut M

机构信息

Universitäts-Augenklinik Tübingen, Schleichstr. 12-16, 72076, Tübingen, Deutschland,

出版信息

Ophthalmologe. 2014 Dec;111(12):1219-32; quiz 1233-4. doi: 10.1007/s00347-014-3201-2.

Abstract

Intermediate uveitis is a form of intraocular inflammation in which the vitreous body is the major site of inflammation. Intermediate uveitis is primarily treated medicinally and systemic corticosteroids are the mainstay of therapy. When recurrence of uveitis or side effects occur during corticosteroid therapy an immunosuppressive treatment is required. Cyclosporine A is the only immunosuppressive agent that is approved for therapy of uveitis in Germany; however, other immunosuppressive drugs have also been shown to be effective and well-tolerated in patients with intermediate uveitis. In severe therapy-refractory cases when conventional immunosuppressive therapy has failed, biologics can be used. In patients with unilateral uveitis or when the systemic therapy is contraindicated because of side effects, an intravitreal steroid treatment can be carried out. In certain cases a vitrectomy may be used.

摘要

中间葡萄膜炎是一种眼内炎症,其中玻璃体是主要的炎症部位。中间葡萄膜炎主要采用药物治疗,全身使用皮质类固醇是治疗的主要手段。当皮质类固醇治疗期间葡萄膜炎复发或出现副作用时,需要进行免疫抑制治疗。环孢素A是德国唯一被批准用于治疗葡萄膜炎的免疫抑制剂;然而,其他免疫抑制药物在中间葡萄膜炎患者中也已显示出有效且耐受性良好。在常规免疫抑制治疗失败的严重治疗难治性病例中,可以使用生物制剂。对于单侧葡萄膜炎患者或因副作用而禁忌全身治疗的患者,可以进行玻璃体内类固醇治疗。在某些情况下,可以采用玻璃体切除术。

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