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利伐沙班与扁桃体切除术

Tonsillectomy on rivaroxaban.

作者信息

Saini Alok T, Schorn Victor J, Lin Fred Y

机构信息

Department of Otolaryngology, Head and Neck Surgery, Mount Sinai Hospital New York, New York.

Department of Otolaryngology, Head and Neck Surgery, Mount Sinai Hospital New York, New York.

出版信息

Am J Otolaryngol. 2015 Mar-Apr;36(2):280-2. doi: 10.1016/j.amjoto.2014.10.013. Epub 2014 Oct 22.

Abstract

OBJECTIVE

The objective of this case report is to increase awareness regarding a new category of drugs, new direct oral anticoagulants (specifically, rivaroxaban), which are increasingly being used instead of the more traditional vitamin K antagonists, to highlight the current recommendations for perioperative management of rivaroxaban, and to demonstrate a clinical scenario where a tonsillectomy was successfully performed in a patient requiring anticoagulation with rivaroxaban.

METHODS

A literature review and a case report are presented. PubMed was reviewed for evidence based recommendations regarding the perioperative management of rivaroxaban and the recommendations for reversal in the event of a hemorrhagic complication. There is no evidence in the literature regarding the use of rivaroxaban in patients undergoing tonsillectomy. We present the case of a 38year old female on rivaroxaban for history of deep vein thrombosis and pulmonary embolism who successfully underwent tonsillectomy using the current recommendations for perioperative management of rivaroxaban.

RESULTS

Our patient had no thrombotic or hemorrhagic complications during the postoperative period. This is the first report in the literature regarding the use of a new direct oral anticoagulant, rivaroxaban, in the setting of tonsillectomy. This case report suggests that tonsillectomy can be performed in patients anticoagulated with rivaroxaban.

CONCLUSION

With the increasingly common use of new direct oral anticoagulants for short and long-term anticoagulation, further research is necessary to compare the efficacy and safety profile of the new direct oral anticoagulants to the more traditional vitamin K antagonists when performing tonsillectomy. Otolaryngologists should be familiar with the new oral anticoagulants and understand the proposed perioperative management as practitioners are increasingly likely to encounter patients using this new class of medication in clinical practice.

摘要

目的

本病例报告的目的是提高对一类新型药物——新型直接口服抗凝剂(具体为利伐沙班)的认识,这类药物正越来越多地被用于替代更为传统的维生素K拮抗剂;强调利伐沙班围手术期管理的当前建议;并展示一例在需要使用利伐沙班进行抗凝治疗的患者中成功实施扁桃体切除术的临床案例。

方法

呈现一篇文献综述和一例病例报告。检索了PubMed,以获取关于利伐沙班围手术期管理的循证建议以及出血并发症时的逆转建议。文献中没有关于利伐沙班在扁桃体切除术中应用的证据。我们报告一例38岁女性,因有深静脉血栓形成和肺栓塞病史而服用利伐沙班,该患者按照利伐沙班围手术期管理的当前建议成功接受了扁桃体切除术。

结果

我们的患者在术后期间未出现血栓形成或出血并发症。这是文献中关于在扁桃体切除术中使用新型直接口服抗凝剂利伐沙班的首例报告。该病例报告表明,服用利伐沙班抗凝的患者可以进行扁桃体切除术。

结论

随着新型直接口服抗凝剂越来越普遍地用于短期和长期抗凝,在进行扁桃体切除术时,有必要进一步研究以比较新型直接口服抗凝剂与更为传统的维生素K拮抗剂的疗效和安全性。耳鼻喉科医生应熟悉新型口服抗凝剂,并了解建议的围手术期管理,因为临床医生在临床实践中越来越可能遇到使用这类新型药物的患者。

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