儿童特应性皮炎：临床特征、病理生理学及治疗
Atopic dermatitis in children: clinical features, pathophysiology, and treatment.
作者信息
Lyons Jonathan J, Milner Joshua D, Stone Kelly D
机构信息
Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Genetics and Pathophysiology of Allergy Section, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
出版信息
Immunol Allergy Clin North Am. 2015 Feb;35(1):161-83. doi: 10.1016/j.iac.2014.09.008. Epub 2014 Nov 21.
Abstract
Atopic dermatitis (AD) is a chronic, relapsing, highly pruritic skin condition resulting from disruption of the epithelial barrier and associated immune dysregulation in the skin of genetically predisposed hosts. AD generally develops in early childhood, has a characteristic age-dependent distribution and is commonly associated with elevated IgE, peripheral eosinophilia, and other allergic diseases. Medications such as antihistamines have demonstrated poor efficacy in controlling AD-associated itch. Education of patients regarding the primary underlying defects and provision of a comprehensive skin care plan is essential for disease maintenance and management of flares.
摘要
特应性皮炎（AD）是一种慢性、复发性、高度瘙痒的皮肤病，由遗传易感性宿主皮肤中的上皮屏障破坏和相关免疫失调引起。AD通常在儿童早期发病，具有特征性的年龄依赖性分布，并且通常与IgE升高、外周嗜酸性粒细胞增多以及其他过敏性疾病相关。抗组胺药等药物在控制AD相关瘙痒方面疗效不佳。对患者进行关于主要潜在缺陷的教育并提供全面的皮肤护理计划对于疾病维持和发作管理至关重要。
相似文献
1
Atopic dermatitis in children: clinical features, pathophysiology, and treatment.儿童特应性皮炎：临床特征、病理生理学及治疗
Immunol Allergy Clin North Am. 2015 Feb;35(1):161-83. doi: 10.1016/j.iac.2014.09.008. Epub 2014 Nov 21.
2
Updates in atopic dermatitis for the primary care physician: A review of advances in the understanding and treatment of atopic dermatitis.特应性皮炎的更新：对特应性皮炎理解和治疗进展的综述。
Dis Mon. 2024 Apr;70(4):101687. doi: 10.1016/j.disamonth.2024.101687. Epub 2024 Jan 25.
3
Clinical management of atopic dermatitis: practical highlights and updates from the atopic dermatitis practice parameter 2012.特应性皮炎的临床管理：2012年特应性皮炎实践参数的实用要点与更新
J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):361-9; quiz 370. doi: 10.1016/j.jaip.2014.02.015. Epub 2014 Apr 25.
4
Adjunctive Management of Itch in Atopic Dermatitis.特应性皮炎瘙痒的辅助治疗
Dermatol Clin. 2017 Jul;35(3):373-394. doi: 10.1016/j.det.2017.02.011. Epub 2017 May 6.
5
Treatment of Eczema: Corticosteroids and Beyond.湿疹的治疗：皮质类固醇及其他方法。
Clin Rev Allergy Immunol. 2016 Dec;51(3):249-262. doi: 10.1007/s12016-015-8486-7.
6
Atopic dermatitis: an overview.特应性皮炎概述。
Am Fam Physician. 2012 Jul 1;86(1):35-42.
7
Atopic Dermatitis: A Common Pediatric Condition and Its Evolution in Adulthood.特应性皮炎：一种常见的儿科疾病及其在成年期的演变。
Med Clin North Am. 2015 Nov;99(6):1269-85, xii. doi: 10.1016/j.mcna.2015.07.006. Epub 2015 Sep 16.
8
Darier Disease Presenting with Recurrent Kaposi Varicelliform Eruption in a 10-year-old Boy with Seborrheic Dermatitis.患脂溢性皮炎的 10 岁男孩反复出现卡波西水痘样疹，诊断为 Darier 病。
Acta Dermatovenerol Croat. 2021 Nov;29(4):238-240.
9
ETFAD/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children.欧洲皮肤病与性病学会/欧洲变态反应与临床免疫学会湿疹工作组2020年关于成人和儿童特应性皮炎诊断与治疗的立场文件。
J Eur Acad Dermatol Venereol. 2020 Dec;34(12):2717-2744. doi: 10.1111/jdv.16892. Epub 2020 Nov 17.
10
Pathophysiology and Management of Mild to Moderate Pediatric Atopic Dermatitis.儿童轻度至中度特应性皮炎的病理生理学和治疗管理。
J Pediatr Health Care. 2018 Mar-Apr;32(2):S2-S12. doi: 10.1016/j.pedhc.2017.10.002.
引用本文的文献
1
Exploring the role of the Th9/IL-9 axis in atopic dermatitis: analysis of Th9 cells, PU.1 expression and serum IL-9 levels.探索Th9/IL-9轴在特应性皮炎中的作用：Th9细胞、PU.1表达及血清IL-9水平分析
Immunol Res. 2025 Jul 30;73(1):114. doi: 10.1007/s12026-025-09671-0.
2
Microbiome and pediatric leukemia, diabetes, and allergies: Systematic review and meta-analysis.微生物组与小儿白血病、糖尿病和过敏：系统评价与荟萃分析。
PLoS One. 2025 May 20;20(5):e0324167. doi: 10.1371/journal.pone.0324167. eCollection 2025.
3
The primary mechanisms underlying atopic dermatitis.特应性皮炎的主要潜在机制。
Tunis Med. 2025 Jan 5;103(1):65-72. doi: 10.62438/tunismed.v103i1.5220.
4
Unmet Medical Needs and Early Referral of Pediatric Atopic Dermatitis: An Expert Modified Delphi Consensus from Saudi Arabia.儿童特应性皮炎未满足的医疗需求及早期转诊：来自沙特阿拉伯的专家改良德尔菲共识
Dermatol Res Pract. 2022 Aug 11;2022:5636903. doi: 10.1155/2022/5636903. eCollection 2022.
5
Antibacterial and Immunosuppressive Effects of a Novel Marine Brown Alga-Derived Ester in Atopic Dermatitis.新型海洋褐藻衍生酯在特应性皮炎中的抗菌和免疫抑制作用。
Mar Drugs. 2024 Jul 30;22(8):354. doi: 10.3390/md22080354.
6
Atopic dermatitis in Ethiopian children: a multicenter study of clinical severity, characteristics, and sociodemographic factors.埃塞俄比亚儿童的特应性皮炎：一项关于临床严重程度、特征和社会人口学因素的多中心研究。
Front Med (Lausanne). 2024 Jul 15;11:1410310. doi: 10.3389/fmed.2024.1410310. eCollection 2024.
7
The challenge of diagnosing and classifying eosinophilia and eosinophil disorders: A review.嗜酸性粒细胞增多症及嗜酸性粒细胞疾病的诊断与分类挑战：综述
Cent Eur J Immunol. 2024;49(1):60-69. doi: 10.5114/ceji.2024.136512. Epub 2024 Apr 19.
8
Eczema Herpeticum Misdiagnosed as Facial Cellulitis in an African American Male.一名非裔美国男性的疱疹样湿疹被误诊为面部蜂窝织炎
Cureus. 2024 Apr 15;16(4):e58328. doi: 10.7759/cureus.58328. eCollection 2024 Apr.
9
Dupilumab Safety and Efficacy up to 1 Year in Children Aged 6 Months to 5 Years with Atopic Dermatitis: Results from a Phase 3 Open-Label Extension Study.度普利尤单抗治疗 6 个月至 5 岁中重度特应性皮炎患儿 1 年的安全性和疗效：一项开放标签扩展研究的结果。
Am J Clin Dermatol. 2024 Jul;25(4):655-668. doi: 10.1007/s40257-024-00859-y. Epub 2024 May 14.
10
Unraveling the skin; a comprehensive review of atopic dermatitis, current understanding, and approaches.揭开皮肤之谜：特应性皮炎的全面综述、现有认识和方法。
Front Immunol. 2024 Mar 4;15:1361005. doi: 10.3389/fimmu.2024.1361005. eCollection 2024.
本文引用的文献
1
Autosomal recessive phosphoglucomutase 3 (PGM3) mutations link glycosylation defects to atopy, immune deficiency, autoimmunity, and neurocognitive impairment.常染色体隐性磷酸葡萄糖变位酶3（PGM3）突变将糖基化缺陷与特应性、免疫缺陷、自身免疫和神经认知障碍联系起来。
J Allergy Clin Immunol. 2014 May;133(5):1400-9, 1409.e1-5. doi: 10.1016/j.jaci.2014.02.013. Epub 2014 Feb 28.
2
Management of difficult-to-treat atopic dermatitis.特应性皮炎的治疗困境。
J Allergy Clin Immunol Pract. 2013 Mar;1(2):142-51. doi: 10.1016/j.jaip.2012.09.002. Epub 2012 Dec 14.
3
A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.一种感觉神经元表达的白细胞介素-31 受体介导 T 辅助细胞依赖性瘙痒：涉及 TRPV1 和 TRPA1。
J Allergy Clin Immunol. 2014 Feb;133(2):448-60. doi: 10.1016/j.jaci.2013.10.048. Epub 2013 Dec 25.
4
Establishing diagnostic criteria for severe combined immunodeficiency disease (SCID), leaky SCID, and Omenn syndrome: the Primary Immune Deficiency Treatment Consortium experience.建立严重联合免疫缺陷病（SCID）、渗漏性 SCID 和 Omenn 综合征的诊断标准：原发性免疫缺陷治疗联盟的经验。
J Allergy Clin Immunol. 2014 Apr;133(4):1092-8. doi: 10.1016/j.jaci.2013.09.044. Epub 2013 Nov 28.
5
Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting.桥粒芯糖蛋白 1 缺乏导致严重的皮炎、多种过敏和代谢消耗。
Nat Genet. 2013 Oct;45(10):1244-1248. doi: 10.1038/ng.2739. Epub 2013 Aug 25.
6
Multiparameter single-cell profiling of human CD4+FOXP3+ regulatory T-cell populations in homeostatic conditions and during graft-versus-host disease.稳态条件下和移植物抗宿主病期间人 CD4+FOXP3+调节性 T 细胞群体的多参数单细胞分析。
Blood. 2013 Sep 5;122(10):1802-12. doi: 10.1182/blood-2013-02-482539. Epub 2013 Jul 1.
7
"Eczema coxsackium" and unusual cutaneous findings in an enterovirus outbreak.“柯萨奇病毒湿疹”与肠道病毒爆发中的不寻常皮肤表现。
Pediatrics. 2013 Jul;132(1):e149-57. doi: 10.1542/peds.2012-3175. Epub 2013 Jun 17.
8
Why is eczema herpeticum unexpectedly rare?为什么疱疹样湿疹如此罕见？
Antiviral Res. 2013 May;98(2):153-7. doi: 10.1016/j.antiviral.2013.02.010. Epub 2013 Feb 22.
9
Combined DOCK8 and CLEC7A mutations causing immunodeficiency in 3 brothers with diarrhea, eczema, and infections.DOCK8和CLEC7A基因联合突变导致3名患有腹泻、湿疹和感染的兄弟出现免疫缺陷。
J Allergy Clin Immunol. 2013 Feb;131(2):594-7.e1-3. doi: 10.1016/j.jaci.2012.10.062.
10
Atopic dermatitis: a practice parameter update 2012.特应性皮炎：2012 年实践参数更新。
J Allergy Clin Immunol. 2013 Feb;131(2):295-9.e1-27. doi: 10.1016/j.jaci.2012.12.672.
Zotero 插件