G蛋白偶联孤儿受体在肠道炎症中的作用：炎症性肠病的新靶点
Role of G protein-coupled orphan receptors in intestinal inflammation: novel targets in inflammatory bowel diseases.
作者信息
Wasilewski Andrzej, Storr Martin, Zielińska Marta, Fichna Jakub
机构信息
*Department of Biochemistry, Faculty of Medicine, Medical University of Lodz, Lodz, Poland; and †Department of Medicine, Division of Gastroenterology, Ludwig Maximilians University of Munich, Munich, Germany.
出版信息
Inflamm Bowel Dis. 2015 Mar;21(3):666-73. doi: 10.1097/MIB.0000000000000258.
A large number of proteins were classified into the family of G protein-coupled receptors (GPCRs). Based on their characteristic serpentine domain, they are called 7 TM receptors. Presently, their ligands and physiological functions remain unknown. In this review, we summarize what is known on these receptors and discuss the potential use of these orphan GPCRs (GPRs) in the induction or maintenance of remission in inflammatory bowel diseases. We focus on GPRs 30, 41, 43, 55, 119, and 120, where scientific evidence supports a potential role in intestinal inflammation.
大量蛋白质被归类为G蛋白偶联受体（GPCR）家族。基于其特征性的蛇形结构域，它们被称为7次跨膜受体。目前，它们的配体和生理功能尚不清楚。在本综述中，我们总结了关于这些受体的已知信息，并讨论了这些孤儿GPCR（GPR）在炎症性肠病缓解诱导或维持中的潜在用途。我们重点关注GPR 30、41、43、55、119和120，科学证据支持它们在肠道炎症中具有潜在作用。
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