基于两个 1,4-二氮杂双环[2.2.2]辛烷的新型聚阳离子分子的结构-活性关系作为人工核糖核酸酶。
Structure-activity relationships in new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octanes as artificial ribonucleases.
机构信息
Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
Institute of Chemical Biology and Fundamental Medicine, Lavrentiev Ave., 8, Novosibirsk 630090, Russia.
出版信息
Bioorg Chem. 2014 Dec;57:127-131. doi: 10.1016/j.bioorg.2014.10.002. Epub 2014 Oct 24.
PMID:25462988
Abstract
In the present study, we designed and synthesised new polycationic molecules based on two 1,4-diazabicyclo[2.2.2]octane (DABCO) moieties with hydrophobic groups connected by different linkers. The structure and the RNA-cleavage activity relationships of this novel series of artificial ribonucleases (aRNases) were investigated.
摘要
在本研究中，我们设计并合成了基于两个 1,4-二氮杂双环[2.2.2]辛烷（DABCO）部分的新的聚阳离子分子，其中疏水基团通过不同的连接子连接。研究了这一系列新型人工核糖核酸酶（aRNases）的结构与 RNA 切割活性关系。
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