胰腺内的可塑性与去分化：发育、稳态与疾病
Plasticity and dedifferentiation within the pancreas: development, homeostasis, and disease.
作者信息
Puri Sapna, Folias Alexandra E, Hebrok Matthias
机构信息
Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
Diabetes Center, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.
出版信息
Cell Stem Cell. 2015 Jan 8;16(1):18-31. doi: 10.1016/j.stem.2014.11.001. Epub 2014 Nov 20.
Abstract
Cellular identity is established by genetic, epigenetic, and environmental factors that regulate organogenesis and tissue homeostasis. Although some flexibility in fate potential is beneficial to overall organ health, dramatic changes in cellular identity can have disastrous consequences. Emerging data within the field of pancreas biology are revising current beliefs about how cellular identity is shaped by developmental and environmental cues under homeostasis and stress conditions. Here, we discuss the changes occurring in cellular states upon fate modulation and address how our understanding of the nature of this fluidity is shaping therapeutic approaches to pancreatic disorders such as diabetes and cancer.
摘要
细胞身份由调节器官发生和组织稳态的遗传、表观遗传和环境因素决定。尽管命运潜能上的一些灵活性对整体器官健康有益，但细胞身份的剧烈变化可能会带来灾难性后果。胰腺生物学领域的新数据正在修正当前关于在稳态和应激条件下细胞身份如何由发育和环境线索塑造的观点。在这里，我们讨论命运调节时细胞状态发生的变化，并探讨我们对这种流动性本质的理解如何塑造针对糖尿病和癌症等胰腺疾病的治疗方法。
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