Robertson Belinda R, Prestia Davide, Twamley Elizabeth W, Patterson Thomas L, Bowie Christopher R, Harvey Philip D
University of Miami Miller School of Medicine, United States.
University of Miami Miller School of Medicine, United States; University of Genoa, Italy.
Schizophr Res. 2014 Dec;160(1-3):136-41. doi: 10.1016/j.schres.2014.10.037. Epub 2014 Nov 7.
Deficits in real world social functioning are common in people with schizophrenia and the treatment of social skills deficits has been a long-time treatment strategy. However, negative (i.e., deficit) symptoms also appear to contribute to real-world social dysfunction. In this study, we combined data from three separate studies of people with schizophrenia (total n=561) who were assessed with identical methods. We examined the prediction of real-world social functioning, rated by high contact clinicians, and compared the influence of negative symptoms and social skills measured with performance-based methods on these outcomes. Negative symptom severity accounted for 20% of the variance in real-world social functioning, with social skills adding an incremental 2%. This 2% variance contribution was the same when social skills were forced into a regression model prior to negative symptom severity. When we examined individual negative symptoms, prediction of real-world social functioning increased to 28%, with active and passive social avoidance entering the equation. Adding depression into the predictor model improved the prediction of real-world social functioning significantly, but minimally (4% variance). Social skills contribute to real-world social outcomes, but treating negative symptoms appears to be a possible path for improving real-world social functioning in this population.
现实世界社交功能缺陷在精神分裂症患者中很常见,社交技能缺陷的治疗一直是一种长期的治疗策略。然而,阴性(即缺陷)症状似乎也导致了现实世界中的社交功能障碍。在本研究中,我们合并了三项针对精神分裂症患者(总计n = 561)的独立研究数据,这些患者采用相同方法进行评估。我们考察了由频繁接触患者的临床医生评定的现实世界社交功能的预测情况,并比较了基于表现的方法所测量的阴性症状和社交技能对这些结果的影响。阴性症状严重程度占现实世界社交功能变异的20%,社交技能额外增加了2%。当社交技能在阴性症状严重程度之前被纳入回归模型时,这2%的变异贡献是相同的。当我们考察个体阴性症状时,现实世界社交功能的预测增加到28%,主动和被动社交回避也纳入了方程。将抑郁纳入预测模型显著提高了对现实世界社交功能的预测,但提升幅度很小(4%的变异)。社交技能有助于现实世界的社交结果,但治疗阴性症状似乎是改善该人群现实世界社交功能的一条可行途径。