Qu Xiao, Zhang Tiehong, Ma Honghai, Sui Ping, Du Jiajun
Institute of Oncology, Shandong Provincial Hospital Affiliated to Shandong University, Shandong University, 324 Jingwu Road, Jinan, 250021, PR China.
Future Oncol. 2014 Nov;10(14):2149-59. doi: 10.2217/fon.14.121.
The association of preoperative red blood cell indexes in non-anemic patients undergoing lung resections for non-small-cell lung cancer with recurrence-free survival (RFS) and overall survival (OS) has never been investigated.
We retrospectively examined the impact of preoperative red blood cell indexes on RFS and OS and the relationships between the indexes and clinicopathological factors in lung cancer.
A total of 649 patients were evaluated. The mean corpuscular hemoglobin concentration was showed as an independent prognostic factor in all patients for OS (hazard ratio [HR]: 0.697; 95% CI: 0.502-0.969; p = 0.032) and RFS (HR: 0.688; 95% CI: 0.519-0.914; p = 0.010). The mean corpuscular volume was an independent prognostic factor in all patients for OS (HR: 0.589; 95% CI: 0.380-0.912; p = 0.018), but not for RFS (HR: 0.684; 95% CI: 0.461-1.015; p = 0.059).
In conclusion, the results of this study suggest that mean corpuscular hemoglobin concentration is an independent prognostic factor for OS and RFS in non-small-cell lung cancer.
对于接受非小细胞肺癌肺切除术的非贫血患者，术前红细胞指数与无复发生存期（RFS）和总生存期（OS）之间的关联从未被研究过。
我们回顾性研究了术前红细胞指数对RFS和OS的影响，以及这些指数与肺癌临床病理因素之间的关系。
共评估了649例患者。在所有患者中，平均红细胞血红蛋白浓度是OS（风险比[HR]：0.697；95%置信区间：0.502 - 0.969；p = 0.032）和RFS（HR：0.688；95%置信区间：0.519 - 0.914；p = 0.010）的独立预后因素。平均红细胞体积是所有患者OS（HR：0.589；95%置信区间：0.380 - 0.912；p = 0.018）的独立预后因素，但不是RFS的独立预后因素（HR：0.684；95%置信区间：0.461 - 1.015；p = 0.059）。
总之，本研究结果表明，平均红细胞血红蛋白浓度是非小细胞肺癌OS和RFS的独立预后因素。
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