Nardini Stefano, Annesi-Maesano Isabella, Del Donno Mario, Delucchi Maurizio, Bettoncelli Germano, Lamberti Vincenzo, Patera Carlo, Polverino Mario, Russo Antonio, Santoriello Carlo, Soverina Patrizio
Pulmonary and TB Unit, Vittorio Veneto General Hospital, Vittorio Veneto, TV, Italy.
EPAR, INSERM UMRS-1136 IPLESP, Paris, France ; EPAR, Paris Université Pierre et Marie Curie, UMRS-1136 IPLESP, Paris, France.
Multidiscip Respir Med. 2014 Sep 3;9(1):46. doi: 10.1186/2049-6958-9-46. eCollection 2014.
Respiratory diseases in Italy already now represent an emergency (they are the 3(rd) ranking cause of death in the world, and the 2(nd) if Lung cancer is included). In countries similar to our own, they result as the principal cause for a visit to the general practitioner (GP) and the second main cause after injury for recourse to Emergency Care. Their frequency is probably higher than estimated (given that respiratory diseases are currently underdiagnosed). The trend is towards a further increase due to epidemiologic and demographic factors (foremost amongst which are the widespread diffusion of cigarette smoking, the increasing mean age of the general population, immigration, and pollution). Within the more general problem of chronic disease care, chronic respiratory diseases (CRDs) constitute one of the four national priorities in that they represent an important burden for society in terms of mortality, invalidity, and direct healthcare costs. The strategy suggested by the World Health Organization (WHO) is an integrated approach consisting of three goals: inform about health, reduce risk exposure, improve patient care. The three goals are translated into practice in the three areas of prevention (1-primary, 2-secondary, 3-tertiary) as: 1) actions of primary (universal) prevention targeted at the general population with the aim to control the causes of disease, and actions of Predictive Medicine - again addressing the general population but aimed at measuring the individual's risk for disease insurgence; 2) actions of early diagnosis targeted at groups or - more precisely - subgroups identified as at risk; 3) continuous improvement and integration of care and rehabilitation support - destined at the greatest possible number of patients, at all stages of disease severity. In Italy, COPD care is generally still inadequate. Existing guidelines, institutional and non-institutional, are inadequately implemented: the international guidelines are not always adaptable to the Italian context; the document of the Agency for Regional Healthcare Services (AGE.NA.S) is a more suited compendium for consultation, and the recent joint statement on integrated COPD management of the three major Italian scientific Associations in the respiratory area together with the contribution of a Society of General Medicine deals prevalently with some critical issues (appropriateness of diagnosis, pharmacological treatment, rehabilitation, continuing care); also the document "Care Continuity: Chronic Obstructive Pulmonary Disease (COPD)" of the Global Alliance against chronic Respiratory Diseases (GARD)-Italy does not treat in depth the issue of early diagnosis. The present document - produced by the AIMAR (Interdisciplinary Association for Research in Lung Disease) Task Force for early diagnosis of chronic respiratory disease based on the WHO/GARD model and on available evidence and expertise -after a general examination of the main epidemiologic aspects, proposes to integrate the above-mentioned existing documents. In particular: a) it formally indicates on the basis of the available evidence the modalities and the instruments necessary for carrying out secondary prevention at the primary care level (a pro-active,'case-finding'approach; assessment of the individual's level of risk of COPD; use of short questionnaires for an initial screening based on symptoms; use of simple spirometry for the second level of screening); b) it identifies possible ways of including these activities within primary care practice; c) it places early diagnosis within the "systemic", consequential management of chronic respiratory diseases, which will be briefly described with the aid of schemes taken from the Italian and international reference documents.
意大利的呼吸系统疾病目前已构成紧急情况(它们是全球第三大致死原因,若计入肺癌则为第二大致死原因)。在与我国类似的国家,呼吸系统疾病是患者拜访全科医生的主要原因,也是仅次于受伤后寻求急诊护理的第二大主要原因。其发病频率可能高于估计值(鉴于目前呼吸系统疾病存在诊断不足的情况)。由于流行病学和人口统计学因素(其中最主要的是吸烟的广泛传播、总人口平均年龄的增加、移民以及污染),发病趋势呈进一步上升态势。在慢性病护理这一更为普遍的问题中,慢性呼吸系统疾病(CRDs)构成了四大国家优先事项之一,因为它们在死亡率、残疾率和直接医疗费用方面给社会带来了重大负担。世界卫生组织(WHO)建议的策略是一种综合方法,包括三个目标:宣传健康知识、减少风险暴露、改善患者护理。这三个目标在预防的三个领域(1 - 一级预防、2 - 二级预防、3 - 三级预防)转化为实际行动如下:1)针对普通人群的一级(普遍)预防行动,旨在控制疾病病因,以及预测医学行动——同样针对普通人群,但旨在衡量个体发病风险;2)针对被确定为有风险的群体或更确切地说是亚组的早期诊断行动;3)持续改善并整合护理及康复支持——针对尽可能多的患者,涵盖疾病严重程度的各个阶段。在意大利,慢性阻塞性肺疾病(COPD)的护理总体上仍然不足。现有的机构和非机构指南实施不力:国际指南并不总是适用于意大利的情况;地区医疗服务机构(AGE.NA.S)的文件是更适合参考的汇编,而意大利呼吸领域三大主要科学协会最近关于COPD综合管理的联合声明以及一个普通医学协会的贡献主要涉及一些关键问题(诊断的适当性、药物治疗、康复、持续护理);全球抗击慢性呼吸系统疾病联盟(GARD)意大利分会的文件《护理连续性:慢性阻塞性肺疾病(COPD)》也未深入探讨早期诊断问题。本文件由肺病研究跨学科协会(AIMAR)慢性呼吸系统疾病早期诊断特别工作组根据WHO/GARD模型以及现有证据和专业知识编写,在对主要流行病学方面进行总体审视后,提议整合上述现有文件。具体而言:a)根据现有证据正式指明在初级保健层面开展二级预防所需的方式和工具(一种积极主动的“病例发现”方法;评估个体患COPD的风险水平;使用基于症状的简短问卷进行初步筛查;使用简单肺活量测定法进行二级筛查);b)确定将这些活动纳入初级保健实践的可能方式;c)将早期诊断置于慢性呼吸系统疾病的“系统性”、连贯性管理之中,这将借助意大利和国际参考文件中的图表进行简要描述。