肝细胞生长因子：炎症和自身免疫的调节剂。
Hepatocyte growth factor: A regulator of inflammation and autoimmunity.
机构信息
Department of Pathology and Immunology, Faculty of Medicine, University of Geneva, Geneva, Switzerland; Department of Clinical Neurosciences, Division of Neurology, Unit of Neuroimmunology and Multiple Sclerosis, University Hospital of Geneva, Geneva, Switzerland.
Center for Advanced Research and Education, Asahikawa Medical University, Asahikawa, Japan.
出版信息
Autoimmun Rev. 2015 Apr;14(4):293-303. doi: 10.1016/j.autrev.2014.11.013. Epub 2014 Dec 1.
Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases. HGF was reported to prevent and attenuate disease progression by influencing multiple pathophysiological processes involved in inflammatory and immune response, including cell migration, maturation, cytokine production, antigen presentation, and T cell effector function. In this review, we discuss the actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases.
肝细胞生长因子（HGF）是一种多效细胞因子，经过几十年的广泛研究，最近才被认为是介导多种炎症和自身免疫性疾病保护的关键因素。据报道，HGF 通过影响炎症和免疫反应中涉及的多种病理生理过程，包括细胞迁移、成熟、细胞因子产生、抗原呈递和 T 细胞效应功能，来预防和减轻疾病进展。在这篇综述中，我们讨论了 HGF 在炎症和免疫中的作用和机制，以及该因子在治疗炎症和自身免疫性疾病方面的治疗潜力。
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