Li Fan, Sun Gang, Yang Yun-Sheng, Cui Li-Hong, Peng Li-Hua, Guo Xu, Wang Wei-Feng, Yan Bin, Zhang Lanjing
Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, 100853, China.
Department of Gastroenterology and Hepatology, Peking University International Hospital, Beijing, 102206, China.
J Huazhong Univ Sci Technolog Med Sci. 2014 Dec;34(6):808-814. doi: 10.1007/s11596-014-1357-2. Epub 2014 Dec 6.
To investigate the known and new factors associated with uninvestigated dyspepsia (UD), we surveyed 8600 Chinese navy personnel with offshore training shorter than 1 month or longer than 9 months per year. All respondents were required to complete a questionnaire covering demographics, the Chinese version of the Rome III survey, eating habits, life styles, and medical and family history. The response rate was 94.3% (8106/8600) with 4899 respondents qualified for analysis, including 1046 with offshore training and 3853 with onshore training. The prevalence of UD was higher in the offshore group than in the onshore group (12.6% vs. 6.9%, P<0.001), with a general prevalence of 8.1%. The subjects with offshore training were more likely to suffer from UD and postprandial distress syndrome (OR=1.955, 95% CI 1.568-2.439, P<0.001 and OR=1.789, 95% CI 1.403-2.303, P<0.001, respectively). The multivariate logistic regression analysis showed UD was associated with offshore training (OR=1.580, 95% CI 1.179-2.118, P=0.002), family history (OR=1.765, 95% CI 1.186-2.626, P=0.005) and smoking (OR=1.270, 95% CI 1.084-1.488, P=0.003), but not with alcohol drinking. The association between dysentery history and UD was undetermined/borderline (P=0.056-0.069). In conclusion, we identified offshore training as a new factor associated with UD, and also confirmed 2 known associated factors, family history and smoking.
为调查与未经检查的消化不良(UD)相关的已知和新因素,我们对8600名中国海军人员进行了调查,这些人员每年的海上训练时间短于1个月或长于9个月。所有受访者都被要求完成一份问卷,内容涵盖人口统计学、中文版罗马III调查问卷、饮食习惯、生活方式以及医疗和家族史。回复率为94.3%(8106/8600),其中4899名受访者符合分析条件,包括1046名接受海上训练的人员和3853名接受陆上训练的人员。UD的患病率在海上训练组高于陆上训练组(12.6%对6.9%,P<0.001),总体患病率为8.1%。接受海上训练的受试者更易患UD和餐后不适综合征(分别为OR=1.955,95%CI 1.568 - 2.439,P<0.001和OR=1.789,95%CI 1.403 - 2.303,P<0.001)。多因素逻辑回归分析显示,UD与海上训练(OR=1.580,95%CI 1.179 - 2.118,P=0.002)、家族史(OR=1.765,95%CI 1.186 - 2.626,P=0.005)和吸烟(OR=1.270,95%CI 1.084 - 1.488,P=0.003)有关,但与饮酒无关。痢疾病史与UD之间的关联未确定/处于临界状态(P=0.056 - 0.069)。总之,我们确定海上训练是与UD相关的一个新因素,同时也证实了两个已知的相关因素,即家族史和吸烟。