精神分裂症患者同胞的认知发展改变。
Altered cognitive development in the siblings of individuals with schizophrenia.
作者信息
Barch Deanna M, Cohen Rachel, Csernansky John
机构信息
Departments of Psychology, Psychiatry and Radiology, Washington University.
Department of Psychology, Washington University.
出版信息
Clin Psychol Sci. 2014 Mar 1;2(2):138-151. doi: 10.1177/2167702613496244.
The goal of the current study was to further investigate the late neurodevelopmental hypothesis of schizophrenia by examining cross-sectional, age-related changes in cognitive function among young adult: 1) siblings of individuals with schizophrenia (N = 66); (2) healthy control participants (N = 77); and (3) the siblings of healthy controls (N = 77). All subjects participated in a battery of tasks in four domains: 1) IQ; 2) working memory; 3) episodic memory; and 4) executive function. We found significant group differences in the relationships between age and performance in working memory and episodic memory, with similar patterns for executive function and verbal IQ. The siblings of individuals with schizophrenia showed impaired performance in working memory, episodic memory, and executive function. In addition, healthy controls and/or their siblings showed age-related improvements in all four cognitive domains, while the siblings of individuals with schizophrenia only showed this for verbal IQ.
本研究的目的是通过检查年轻成年人认知功能的横断面、与年龄相关的变化，进一步探究精神分裂症的晚期神经发育假说：（1）精神分裂症患者的兄弟姐妹（N = 66）；（2）健康对照参与者（N = 77）；以及（3）健康对照者的兄弟姐妹（N = 77）。所有受试者都参与了四个领域的一系列任务：（1）智商；（2）工作记忆；（3）情景记忆；以及（4）执行功能。我们发现，在工作记忆和情景记忆中，年龄与表现之间的关系存在显著的组间差异，执行功能和言语智商也有类似模式。精神分裂症患者的兄弟姐妹在工作记忆、情景记忆和执行功能方面表现受损。此外，健康对照者和/或他们的兄弟姐妹在所有四个认知领域都表现出与年龄相关的改善，而精神分裂症患者的兄弟姐妹仅在言语智商方面有此表现。
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