Khoury Loren, Dangodara Amish A, Lee Jung-Ah, Lovejoy Marianne, Amin Alpesh N
Internal Medicine Resident, University of Minnesota, Minneapolis, MN.
Hosp Pract (1995). 2014 Dec;42(5):89-99. doi: 10.3810/hp.2014.12.1162.
Venous thromboembolism (VTE), including pulmonary embolism and deep vein thrombosis, is a major cause of morbidity and mortality. It results in approximately 300 000 deaths in the United States each year, and two thirds of VTE events are hospital acquired. However, VTE prophylaxis for hospitalized patients remains suboptimal.
Assess the effect of a physician-mandated VTE prophylaxis computerized order set on the rates of hospital acquired VTE.
A retrospective prevalence study of hospitalized patients pre- and postimplementation of a mandatory VTE order set. Additionally, the Joint Commission VTE Core Measures data was tracked for improvements postimplementation.
At baseline, 73% of patients received appropriate prophylaxis (n = 148) compared with 90% (n = 192) postintervention (P = 0.015). The percentage of patients who received VTE prophylaxis within 24 hours of arrival at the hospital increased from a baseline of 73% to 93% postimplementation (P = 0.0004). Hospital-acquired VTE prevalence rates decreased from 2% (4 cases) to 0.05% (1 case; P = 0.37) post intervention. The incidence of potentially preventable VTE cases (the Joint Commission's core measure 6) decreased from 3.9% to 0% (P = 0.39). These differences were not statistically significant, but they are clinically significant. These results were also sustained over time.
This study demonstrates that a mandated physician VTE order set ensures that nearly all patients will be stratified for VTE risk and provided with prophylaxis based on their risk category. Adhering to the evidence-based clinical practice guidelines from the American College of Chest Physicians is effective in improving prophylaxis and decreasing the rate of hospital-acquired VTE in hospitalized patients, and in decreasing the rate of preventable VTE cases based on the Joint Commission's core measure 6.
静脉血栓栓塞症(VTE),包括肺栓塞和深静脉血栓形成,是发病和死亡的主要原因。在美国,每年约有30万人死于该病,且三分之二的VTE事件是在医院获得的。然而,住院患者的VTE预防措施仍未达到最佳状态。
评估医生强制要求的VTE预防计算机医嘱集对医院获得性VTE发生率的影响。
对实施强制性VTE医嘱集前后的住院患者进行回顾性患病率研究。此外,还跟踪了联合委员会VTE核心指标数据在实施后的改善情况。
在基线时,73%的患者接受了适当的预防措施(n = 148),而干预后这一比例为90%(n = 192)(P = 0.015)。在入院后24小时内接受VTE预防措施的患者百分比从基线时的73%增加到实施后的93%(P = 0.0004)。干预后,医院获得性VTE患病率从2%(4例)降至0.05%(1例;P = 0.37)。潜在可预防的VTE病例发生率(联合委员会核心指标6)从3.9%降至0%(P = 0.39)。这些差异虽无统计学意义,但具有临床意义。这些结果也随时间得以维持。
本研究表明,医生强制要求的VTE医嘱集可确保几乎所有患者都能根据VTE风险进行分层,并根据其风险类别接受预防措施。遵循美国胸科医师学会基于证据的临床实践指南,对于改善住院患者的预防措施、降低医院获得性VTE发生率以及根据联合委员会核心指标6降低可预防VTE病例的发生率是有效的。