El-Sayed E M, Abd-Allah A R, Mansour A M, El-Arabey A A
Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Nasr-City, Cairo, Egypt.
J Biochem Mol Toxicol. 2015 Apr;29(4):165-72. doi: 10.1002/jbt.21681. Epub 2014 Dec 8.
The aim of the present study is to assess the possible protective effects of thymol and carvacrol against cisplatin (CP)-induced nephrotoxicity. A single dose of CP {6 mg/kg, intraperitoneally (i.p.)} injected to male rats revealed significant increases in serum urea, creatinine, and tumor necrosis factor alpha levels. It also increased kidney contents of malondialdehyde and caspase-3 activity with significant reduction in serum albumin, kidney content of reduced glutathione as well as catalase, and superoxide dismutase activity as compared to that of the control group. In contrast, administration of thymol {20 mg/kg, orally (p.o.)} and/or carvacrol (15 mg/kg, p.o.) for 14 days before CP injection and for 7 days after CP administration restored the kidney function and examined oxidative stress parameters. In conclusion, thymol was more effective nephroprotective than carvacrol. Moreover, a combination of thymol and carvacrol had a synergistic nephroprotective effect that might be attributed to antioxidant, anti-inflammatory, and antiapoptotic activities.
本研究的目的是评估百里香酚和香芹酚对顺铂（CP）诱导的肾毒性的可能保护作用。给雄性大鼠腹腔注射单次剂量的CP（6mg/kg）后，血清尿素、肌酐和肿瘤坏死因子α水平显著升高。与对照组相比，它还增加了肾脏丙二醛含量和半胱天冬酶-3活性，同时血清白蛋白、肾脏还原型谷胱甘肽含量以及过氧化氢酶和超氧化物歧化酶活性显著降低。相比之下，在注射CP前14天和注射CP后7天口服百里香酚（20mg/kg）和/或香芹酚（15mg/kg）可恢复肾功能并检测氧化应激参数。总之，百里香酚的肾保护作用比香芹酚更有效。此外，百里香酚和香芹酚的组合具有协同肾保护作用，这可能归因于抗氧化、抗炎和抗凋亡活性。
