一种基于ZnO@PNIPAM杂化纳米粒子的新型热和pH响应药物递送系统。
A novel thermal and pH responsive drug delivery system based on ZnO@PNIPAM hybrid nanoparticles.
作者信息
Tan Licheng, Liu Jian, Zhou Weihua, Wei Junchao, Peng Zhiping
机构信息
Department of Chemistry, Nanchang University, Nanchang 330031, China.
Department of Chemistry, Nanchang University, Nanchang 330031, China; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, 220 Handan Road, Shanghai 200433, China.
出版信息
Mater Sci Eng C Mater Biol Appl. 2014 Dec;45:524-9. doi: 10.1016/j.msec.2014.09.031. Epub 2014 Sep 18.
A smart ZnO@PNIPAM hybrid was prepared by grafting thermal responsive poly(N-isopropylacrylamide) (PNIPAM) on zinc oxide (ZnO) nanoparticles via surface-initiated atom transfer radical polymerization (ATRP). The thermal gravimetric analysis (TGA) shows that the grafting amount of PNIPAM was about 38%, and the SEM images show that the PNIPAM chains can prevent the aggregation of ZnO nanoparticles. The responsive properties of ZnO@PNIPAM were measured by photoluminescence spectra, and the results demonstrate that the PNIPAM chains grafted on ZnO surfaces can realize reversible thermal responsive and photoluminescence properties. An anticancer drug, doxorubicin (Dox), was used as a model drug and loaded into the hybrid nanoparticles, and an in vitro drug release test implied that ZnO@PNIPAM could work as a thermal responsive drug delivery system. Furthermore, pH sensitive drug releases were carried out in acetate buffer at pH 5.0 and pH 6.0 and in water at pH7.0, and the results showed evident pH dependency, showing its pH responsive properties.
通过表面引发原子转移自由基聚合（ATRP）将热响应性聚（N-异丙基丙烯酰胺）（PNIPAM）接枝到氧化锌（ZnO）纳米颗粒上，制备了一种智能ZnO@PNIPAM杂化物。热重分析（TGA）表明PNIPAM的接枝量约为38%，扫描电子显微镜（SEM）图像表明PNIPAM链可以防止ZnO纳米颗粒的聚集。通过光致发光光谱测量了ZnO@PNIPAM的响应特性，结果表明接枝在ZnO表面的PNIPAM链可以实现可逆的热响应和光致发光特性。以抗癌药物阿霉素（Dox）作为模型药物，将其负载到杂化纳米颗粒中，体外药物释放试验表明ZnO@PNIPAM可以作为热响应药物递送系统。此外，在pH 5.0和pH 6.0的醋酸盐缓冲液以及pH 7.0的水中进行了pH敏感药物释放实验，结果显示出明显的pH依赖性，表明其具有pH响应特性。
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