Issack Paul S, Barker Jordan, Baker Matthew, Kotwal Suhel Y, Lane Joseph M
New York-Presbyterian Hospital, 170 William Street, New York, NY 10038. E-mail address:
University of Missouri at Kansas City School of Medicine, 2301 Holmes Street, Kansas City, MO 64108.
J Bone Joint Surg Am. 2014 Dec 17;96(24):2091-8. doi: 10.2106/JBJS.N.00083.
➤ Pathologic fracture of the proximal part of the femur resulting from metastatic disease causes severe pain and an inability to walk. Surgical stabilization can be challenging because of bone loss resulting from the underlying metastatic lesions, the potential for major blood loss, and the poor health of the patient.➤ The goal of surgical treatment is the creation of a stable construct to allow early weight-bearing.➤ Pathologic femoral neck fractures secondary to metastases are best managed with arthroplasty.➤ The treatment of intertrochanteric or subtrochanteric fractures is more controversial. Surgical stabilization may be performed with cephalomedullary nailing or arthroplasty. The choice of implant and operative technique is dependent on careful consideration of multiple factors, including the patient's life span, the type of tumor, the perceived response to other therapies, the need for adjuvant radiation therapy and chemotherapy, the location and number of metastatic lesions, and the degree of bone involvement.➤ While the potential for complications is high, surgical stabilization of the proximal part of the femur decreases pain and improves function.
➤ 转移性疾病导致的股骨近端病理性骨折会引起严重疼痛和无法行走。由于潜在转移性病变导致的骨质流失、大出血的可能性以及患者健康状况较差,手术固定可能具有挑战性。
➤ 手术治疗的目标是构建一个稳定的结构以允许早期负重。
➤ 继发于转移瘤的病理性股骨颈骨折最好采用关节置换术治疗。
➤ 转子间或转子下骨折的治疗更具争议性。手术固定可采用髓内钉或关节置换术进行。植入物和手术技术的选择取决于对多种因素的仔细考虑,包括患者的预期寿命、肿瘤类型、对其他治疗的预期反应、辅助放疗和化疗的需求、转移性病变的位置和数量以及骨质受累程度。
➤ 虽然并发症的可能性很高,但股骨近端的手术固定可减轻疼痛并改善功能。