[促肾上腺皮质激素片段的环状类似物对家兔自我刺激和梳理行为的影响]
[Cyclic analogs of ACTH fragments in self-stimulation and grooming behavior in rabbits].
作者信息
Burchuladze R A, Liepkaula I K, Romanovskiĭ P Ia, Chipens G I
出版信息
Biull Eksp Biol Med. 1989 Aug;108(8):214-6.
In present study new cyclic fragments of ACTH EHFRWGKPVG--NH2 and KHFRWG--NH2 were investigated in organization of self-stimulation and grooming behaviour in rabbits. Intracerebroventricular injections of EHFRWGPVG--NH2 in doses of 0.1-2.5 g evoked significant increases of self-stimulation and in doses of 4-5 g suppressed self-stimulation in rabbits. The effect of other fragments KHFRWG--NH2 on self-stimulation was not statistically significant. Both fragments induced excessive grooming behaviour in rabbits. The effects of these fragments persisted of 48-72 hours.
在本研究中，对促肾上腺皮质激素的新环状片段EHFRWGKPVG--NH2和KHFRWG--NH2在兔子自我刺激和梳理行为的组织方面进行了研究。脑室内注射剂量为0.1 - 2.5微克的EHFRWGPVG--NH2可引起兔子自我刺激显著增加，而剂量为4 - 5微克时则抑制兔子的自我刺激。其他片段KHFRWG--NH2对自我刺激的影响无统计学意义。两个片段均诱导兔子出现过度梳理行为。这些片段的作用持续48 - 72小时。
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