Huang Yuefeng, Guo Liying, Qiu Jin, Chen Xi, Hu-Li Jane, Siebenlist Ulrich, Williamson Peter R, Urban Joseph F, Paul William E
Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Nat Immunol. 2015 Feb;16(2):161-9. doi: 10.1038/ni.3078. Epub 2014 Dec 22.
Innate lymphoid cells (ILCs) are lymphocyte-like cells that lack T cell or B cell antigen receptors and mediate protective and repair functions through cytokine secretion. Among these, type 2 ILCs (ILC2 cells) are able to produce type 2 cytokines. We report the existence of an inflammatory ILC2 (iILC2) population responsive to interleukin 25 (IL-25) that complemented IL-33-responsive natural ILC2 (nILC2) cells. iILC2 cells developed into nILC2-like cells in vitro and in vivo and contributed to the expulsion of Nippostrongylus brasiliensis. They also acquired IL-17-producing ability and provided partial protection against Candida albicans. We propose that iILC2 cells are transient progenitors of ILCs mobilized by inflammation and infection that develop into nILC2-like cells or ILC3-like cells and contribute to immunity to both helminths and fungi.
固有淋巴细胞（ILC）是一类淋巴细胞样细胞，缺乏T细胞或B细胞抗原受体，并通过分泌细胞因子介导保护和修复功能。其中，2型ILC（ILC2细胞）能够产生2型细胞因子。我们报道了存在一种对白细胞介素25（IL-25）有反应的炎性ILC2（iILC2）群体，它补充了对IL-33有反应的天然ILC2（nILC2）细胞。iILC2细胞在体外和体内均可发育成nILC2样细胞，并有助于巴西日圆线虫的排出。它们还获得了产生IL-17的能力，并对白色念珠菌提供部分保护。我们提出，iILC2细胞是由炎症和感染动员的ILC的短暂祖细胞，可发育成nILC2样细胞或ILC3样细胞，并有助于对蠕虫和真菌的免疫。
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