[系统性硬化症与职业暴露：关于一名钻孔工-炸药装填工的病例]
[Systemic sclerosis and occupational exposures: About a case in a driller-powderman].
作者信息
Boulanger M, Bienvenu B, Marquignon M-F, Letourneux M, Clin B
机构信息
Service de santé au travail et pathologie professionnelle, CHU Côte-de-Nacre, 14033 Caen cedex, France; Institut de recherche et de formation en santé au travail de Basse-Normandie, faculté de médecine de Caen, 14033 Caen cedex, France.
Service de médecine interne, CHU Côte-de-Nacre, 14033 Caen cedex, France.
出版信息
Rev Med Interne. 2015 Aug;36(8):551-4. doi: 10.1016/j.revmed.2014.09.003. Epub 2014 Dec 22.
INTRODUCTION
Erasmus' syndrome is the association between systemic sclerosis and silica exposure.
CASE REPORT
We report a case of this syndrome in a driller-powderman exposed to silica and nitro compounds contained in explosives.
CONCLUSION
Physiopathology and etiologies of systemic sclerosis are still not well known. However, nitric oxide, a product of nitro compounds metabolism, is involved in the physiopathology of the disease: it seems thus licit to wonder about the consequences of an uncontrolled occupational exposure to nitric oxide on the vascular function, already damaged by systemic sclerosis. To a wider extent, our report highlights the importance of a comprehensive and detailed collection of occupational exposures for patients diagnosed with systemic sclerosis.
引言
伊拉斯谟综合征是系统性硬化症与接触二氧化硅之间的关联。
病例报告
我们报告了一例该综合征病例，患者为一名钻机工 - 炸药装填工，接触了炸药中所含的二氧化硅和硝基化合物。
结论
系统性硬化症的病理生理学和病因仍未完全明确。然而，硝基化合物代谢产物一氧化氮参与了该疾病的病理生理过程：因此，对于一氧化氮不受控制的职业暴露对已因系统性硬化症受损的血管功能的影响进行探究似乎是合理的。更广泛地说，我们的报告强调了对诊断为系统性硬化症的患者进行全面且详细的职业暴露情况收集的重要性。
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