Liu Zuyun, Huang Jiapin, Qian Degui, Chen Fei, Xu Jun, Li Shilin, Jin Li, Chu Xuefeng, Wang Xiaofeng
Unit of Epidemiology, State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 200433 Shanghai, China.
Longevity Research Institute of Rugao, 226500 Jiangsu, China.
Arch Gerontol Geriatr. 2015 Mar-Apr;60(2):354-8. doi: 10.1016/j.archger.2014.12.003. Epub 2014 Dec 10.
CKD, a functional decline or break down of kidney, has been increasingly recognized as a public health problem and a predictor of poor outcomes (i.e., cardiovascular disease, dementia) and mortality among general populations. However, little is known regarding the prevalence and related factors of CKD among Chinese LLI over 95 years of age.
We used data of LLI from the Rugao longevity cohort, a population-based association study conducted in Rugao, a longevity town of China. CKD was defined as an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73 m2. Demographic exposures and biochemical markers were correlated with CKD.
The prevalence of CKD among LLI in Rugao is 23.8%. Traditional risk factors for CKD among general population, such as hypertension, diabetes, and dyslipidemia, did not have associations with CKD. However, overweight, central adiposity, and hyperuricemia were associated with increased risk of CKD, with crude odds ratios of 2.41 (95% CI=1.23-4.69), 2.61 (95% CI=1.42-4.77), and 5.69 (95% CI=2.75-11.76), respectively. In addition, higher magnesium and filtration marker β2 microglobulin (β2M) were associated with CKD, with crude odds ratios of 2.47 (95% CI=1.38-4.43) and 16.38 (95% CI=6.76-39.64), respectively.
We observe a high prevalence and unique related factors of CKD among the LLI in Rugao, which suggest that early screening and risk intervention of CKD are imperative to maintain a high quality of life and postpone the occurrence of poor outcomes.
慢性肾脏病（CKD）是一种肾脏功能衰退或破坏的疾病，日益被视为一个公共卫生问题，也是普通人群不良预后（即心血管疾病、痴呆）和死亡的预测因素。然而，对于95岁以上中国长寿老人中CKD的患病率及相关因素知之甚少。
我们使用了如皋长寿队列中长寿老人的数据，这是在中国长寿之乡如皋进行的一项基于人群的关联研究。CKD被定义为估算肾小球滤过率（eGFR）<60 mL/（min·1.73 m²）。将人口统计学暴露因素和生化指标与CKD进行相关性分析。
如皋长寿老人中CKD的患病率为23.8%。普通人群中CKD的传统危险因素，如高血压、糖尿病和血脂异常，与CKD并无关联。然而，超重、中心性肥胖和高尿酸血症与CKD风险增加相关，粗比值比分别为2.41（95%置信区间=1.23 - 4.69）、2.61（95%置信区间=1.42 - 4.77）和5.69（95%置信区间=2.75 - 11.76）。此外，较高的镁和滤过标志物β2微球蛋白（β2M）与CKD相关，粗比值比分别为2.47（95%置信区间=1.38 - 4.43）和16.38（95%置信区间=6.76 - 39.64）。
我们观察到如皋长寿老人中CKD的患病率较高且存在独特的相关因素，这表明对CKD进行早期筛查和风险干预对于维持高质量生活和推迟不良后果的发生至关重要。
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