Hydroxyl radicals is not a significant intermediate in the vanadate-stimulated oxidation of NAD(P)H by O2.
作者信息
Liochev S I, Fridovich I
机构信息
Institute of Physiology, Bulgarian Academy of Sciences, Sofia.
出版信息
Arch Biochem Biophys. 1989 Nov 15;275(1):40-3. doi: 10.1016/0003-9861(89)90347-0.
PMID:2554810
Abstract
The vanadate-stimulated oxidation of NADH by an enzymatic flux of O2- is inhibited by superoxide dismutase, but not by catalase. Keller et al. (1989, Free Radical Biol. Med. 6, 15-22) observed inhibition by catalase presumably because they used a commercial preparation contaminated with superoxide dismutase. Their proposal, that H2O2 and hydroxyl radical play significant roles in vanadate-stimulation of NAD(P)H oxidation, may be discounted on the basis of these and of previously reported results.
摘要
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