直径小于2厘米的单发肝细胞癌：乙醇注射和射频消融疗效相同吗？

Single hepatocellular carcinoma smaller than 2 cm: are ethanol injection and radiofrequency ablation equally effective?

作者信息

Pompili Maurizio, De Matthaeis Nicoletta, Saviano Antonio, De Sio Ilario, Francica Giampiero, Brunello Franco, Cantamessa Alessandro, Giorgio Antonio, Scognamiglio Umberto, Fornari Fabio, Giangregorio Francesco, Piscaglia Fabio, Gualandi Silvia, Caturelli Eugenio, Roselli Paola, Riccardi Laura, Rapaccini Gian Ludovico

机构信息

Department of Internal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy

Department of Internal Medicine, Università Cattolica del Sacro Cuore, Rome, Italy.

出版信息

Anticancer Res. 2015 Jan;35(1):325-32.

PMID:25550567

Abstract

BACKGROUND/AIM: The impact of radiofrequency ablation (RFA) and percutaneous ethanol injection (PEI) on survival in patients with small hepatocellular carcinoma (HCC) is unclear. We compared their efficacy in cirrhotics with single HCC ≤2 cm.

PATIENTS AND METHODS

Two hundred forty-four cirrhotics with single HCC ≤2 cm treated with PEI (108 cases) or RFA (136 cases) were enrolled in the study. Eighty-one patients in each group were selected for propensity score matching analysis.

RESULTS

The five-year survival was not significantly different (64.7% in PEI and 72.9% in RFA group) but the 5-year recurrence (73.3% in PEI and 49% in RFA group, p=0.023) and local tumor progression (49% in PEI and 30.1% in RFA group, p=0.018) were higher in the PEI group.

CONCLUSION

PEI and RFA are equally effective in treating HCCs smaller than 2 cm in terms of 5-year survival, despite higher cumulative and local recurrence rates, in patients treated with PEI.

摘要

背景/目的：射频消融（RFA）和经皮乙醇注射（PEI）对小肝细胞癌（HCC）患者生存率的影响尚不清楚。我们比较了它们对单个HCC≤2 cm的肝硬化患者的疗效。