股骨转移性黑色素瘤——病例报告并文献复习：病理学家视角
Metastatic Melanoma in the Femur - Case Report with Review of Literature: a Pathologist's Point of View.
作者信息
Costache Mariana, Stoica Alexandra, Contolenco Andreea, Costache Diana, Cirstoiu Catalin, Simionescu Olga, George Simion
机构信息
Department of Pathology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania.
Department of Pathology, Emergency University Hospital Bucharest, Romania.
出版信息
Maedica (Bucur). 2014 Mar;9(1):62-7.
The aim of this case report was to evaluate the histopathological characteristics on a patient with metastases in the femur from malignant melanoma. A review from the literature is also mentioned.We present a case of metastatic malignant melanoma in the femur with known primary site in a 44-year-old-female. Diagnosis was confirmed by histopathology.Malignant melanoma is a cancer that may metastasise in the skeleton. However most of bone metastases are found in the axial skeleton and they rarely involve the femur, as in our case. Only a few case reports are published in the literature. Clinicians must be aware of the varied clinical manifestations of disseminated malignant melanoma.The diagnosis for metastatic malignant melanoma is confirmed due to pathological examination. Immunohistochemical study is useful in diagnosis, mainly when malignant melanoma is poorly differen-tiated.
本病例报告的目的是评估一名股骨发生恶性黑色素瘤转移患者的组织病理学特征。文中还提及了文献综述。我们报告一例44岁女性股骨转移性恶性黑色素瘤病例，其原发部位已知。组织病理学确诊了该病例。恶性黑色素瘤是一种可能转移至骨骼的癌症。然而，大多数骨转移发生在中轴骨骼，像我们这个病例中累及股骨的情况很少见。文献中仅发表了少数病例报告。临床医生必须了解播散性恶性黑色素瘤的各种临床表现。转移性恶性黑色素瘤的诊断通过病理检查得以证实。免疫组织化学研究对诊断很有用，主要适用于恶性黑色素瘤分化较差的情况。
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