白细胞介素-21在免疫与癌症中的作用。

The role of IL-21 in immunity and cancer.

作者信息

Davis Matthew R, Zhu Ziwen, Hansen Dwayne M, Bai Qian, Fang Yujiang

机构信息

Department of Microbiology & Immunology, Des Moines University, Des Moines, Iowa 50312, USA.

Department of Surgery, University of Missouri School of Medicine, Columbia, MO 65212, USA.

出版信息

Cancer Lett. 2015 Mar 28;358(2):107-114. doi: 10.1016/j.canlet.2014.12.047. Epub 2015 Jan 6.

DOI:10.1016/j.canlet.2014.12.047

PMID:25575696

Abstract

Interleukin-21 (IL-21), produced predominantly by CD4+ T cells and natural killer T (NKT) cells, is a newly discovered member of the common γ-chain family of cytokines. It has been implicated in many immunological processes and has been linked to autoimmune diseases, allergies and other inflammatory diseases. In recent years, the role for IL-21 in the pathogenesis of cancer has also been extensively studied. In this review, we will discuss recent advances concerning the role of IL-21 in immunological processes and the pathogenesis of cancer.

摘要

白细胞介素-21（IL-21）主要由CD4 + T细胞和自然杀伤T（NKT）细胞产生，是细胞因子共同γ链家族新发现的成员。它参与了许多免疫过程，并与自身免疫性疾病、过敏和其他炎症性疾病有关。近年来，IL-21在癌症发病机制中的作用也得到了广泛研究。在这篇综述中，我们将讨论关于IL-21在免疫过程和癌症发病机制中作用的最新进展。