载有紫杉醇的胶束可增强纳米药物在肿瘤中的跨血管通透性和滞留性。
Paclitaxel-loaded micelles enhance transvascular permeability and retention of nanomedicines in tumors.
作者信息
Danhier Fabienne, Danhier Pierre, De Saedeleer Christophe J, Fruytier Anne-Catherine, Schleich Nathalie, des Rieux Anne, Sonveaux Pierre, Gallez Bernard, Préat Véronique
机构信息
Université catholique de Louvain, Louvain Drug Research Institute, Advanced Drug Delivery and Biomaterials, Avenue Mounier, 73, B1 73.12, 1200 Brussels, Belgium.
Université catholique de Louvain, Louvain Drug Research Institute, Laboratory of Biomedical Magnetic Resonance, Avenue Mounier, 73, B1 73.08, 1200 Brussels, Belgium.
出版信息
Int J Pharm. 2015 Feb 20;479(2):399-407. doi: 10.1016/j.ijpharm.2015.01.009. Epub 2015 Jan 8.
Paclitaxel (PTX)-loaded polymeric micelles (M-PTX) have been shown to enhance the blood flow and oxygenation of tumors 24h after treatment. We hypothesized that these changes in the tumor microenvironment could lead to an enhancement of the EPR (enhanced permeability and retention) effect. M-PTX, administered 24h before analysis, increased the accumulation of macromolecules, nanoparticles and polymeric micelles in tumors. This increased EPR effect could be linked to normalization of the tumor vasculature and decreased interstitial fluid pressure. M-PTX used as a pre-treatment allowed a more effective delivery of three nanomedicines into tumors: polymeric micelles, liposomes and nanoparticles. These experiments demonstrate an enhanced EPR effect after M-PTX treatment, which lead to better availability and enhanced efficacy of a subsequent treatment with nanomedicines.
载有紫杉醇（PTX）的聚合物胶束（M-PTX）已被证明在治疗后24小时可增强肿瘤的血流和氧合。我们推测，肿瘤微环境中的这些变化可能导致增强的EPR（增强的通透性和滞留）效应。在分析前24小时给予的M-PTX增加了大分子、纳米颗粒和聚合物胶束在肿瘤中的积累。这种增强的EPR效应可能与肿瘤血管系统的正常化和间质液压力降低有关。用作预处理的M-PTX可使三种纳米药物更有效地递送至肿瘤：聚合物胶束、脂质体和纳米颗粒。这些实验证明了M-PTX治疗后EPR效应增强，这导致纳米药物后续治疗的更好可用性和增强疗效。
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