癌症免疫治疗中的生物标志物。
Biomarkers in cancer immunotherapy.
机构信息
Division of Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, the Netherlands.
Department of Theoretical Biology and Bioinformatics, Utrecht University, 3584 CH Utrecht, the Netherlands.
出版信息
Cancer Cell. 2015 Jan 12;27(1):12-4. doi: 10.1016/j.ccell.2014.12.004.
PMID:25584891
Abstract
Antibodies against T cell checkpoint molecules have started to revolutionize cancer treatment. Nevertheless, less than half of all patients respond to these immunotherapies. Recent work supports the potential value of biomarkers that predict therapy outcome and inspires the development of assay systems that interrogate other aspects of the cancer-immunity cycle.
摘要
针对 T 细胞检查点分子的抗体已经开始彻底改变癌症治疗。然而，只有不到一半的患者对这些免疫疗法有反应。最近的工作支持了预测治疗效果的生物标志物的潜在价值，并激发了检测癌症免疫周期其他方面的分析系统的发展。
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