Falvo Michael J, Osinubi Omowunmi Y, Sotolongo Anays M, Helmer Drew A
Epidemiol Rev. 2015;37:116-30. doi: 10.1093/epirev/mxu009. Epub 2015 Jan 14.
More than 2.6 million military personnel have been deployed to recent conflicts in Iraq and Afghanistan and were likely exposed to a variety of airborne hazards during deployment. Despite several epidemiologic reports of increased respiratory symptoms, whether or not these respiratory illnesses lead to reductions in lung function and/or specific pulmonary disease is unclear. We reviewed data published from 2001 to 2014 pertaining to respiratory health in military personnel deployed to Iraq and Afghanistan and found 19 unique studies. Study designs were primarily retrospective and observational in nature with patient symptom reporting and medical encounter data as primary outcome measures. Two case series reported on rare respiratory diseases, and one performed a standardized evaluation of new-onset respiratory symptoms. Respiratory outcomes in relation to proximity to a specific air pollution source (i.e., smoke from burning trash and sulfur mine fire) were described in 2 separate studies. Only 2 longitudinal investigations were identified comparing pre- and postdeployment measurement of exercise capacity. In summary, published data based on case reports and retrospective cohort studies suggest a higher prevalence of respiratory symptoms and respiratory illness consistent with airway obstruction. However, the association between chronic lung disease and airborne hazards exposure requires further longitudinal research studies with objective pulmonary assessments.
超过260万军事人员被部署到近期伊拉克和阿富汗的冲突地区,在部署期间可能接触到各种空气传播危害。尽管有几份流行病学报告称呼吸道症状有所增加,但这些呼吸道疾病是否会导致肺功能下降和/或特定肺部疾病尚不清楚。我们回顾了2001年至2014年期间发表的有关部署到伊拉克和阿富汗的军事人员呼吸健康的数据,共找到19项独立研究。研究设计主要为回顾性和观察性,以患者症状报告和医疗接触数据作为主要结局指标。两个病例系列报告了罕见的呼吸道疾病,还有一个对新发呼吸道症状进行了标准化评估。在两项独立研究中描述了与特定空气污染源(即燃烧垃圾产生的烟雾和硫磺矿火灾)接近程度相关的呼吸结局。仅确定了两项纵向调查,比较了部署前后运动能力的测量结果。总之,基于病例报告和回顾性队列研究发表的数据表明,呼吸道症状和与气道阻塞一致的呼吸道疾病患病率较高。然而,慢性肺病与空气传播危害暴露之间的关联需要进一步进行客观肺部评估的纵向研究。