c-FLIP links mTORC2 to apoptosis.
作者信息
Zhao Liqun, Sun Shi-Yong
机构信息
Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, GA, USA.
出版信息
Oncoscience. 2014 May 20;1(5):306-7. doi: 10.18632/oncoscience.40. eCollection 2014.
Abstract
摘要
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本文引用的文献
1
mTOR complex 2 is involved in regulation of Cbl-dependent c-FLIP degradation and sensitivity of TRAIL-induced apoptosis.
Cancer Res. 2013 Mar 15;73(6):1946-57. doi: 10.1158/0008-5472.CAN-12-3710. Epub 2013 Jan 14.
2
mTOR complex 2 signaling and functions.
Cell Cycle. 2011 Jul 15;10(14):2305-16. doi: 10.4161/cc.10.14.16586.
3
A TNF- and c-Cbl-dependent FLIP(S)-degradation pathway and its function in Mycobacterium tuberculosis-induced macrophage apoptosis.
Nat Immunol. 2009 Aug;10(8):918-26. doi: 10.1038/ni.1754. Epub 2009 Jul 13.
4
Defining the role of mTOR in cancer.
Cancer Cell. 2007 Jul;12(1):9-22. doi: 10.1016/j.ccr.2007.05.008.
5
Upregulation of FLIP(S) by Akt, a possible inhibition mechanism of TRAIL-induced apoptosis in human gastric cancers.
Cancer Sci. 2003 Dec;94(12):1066-73. doi: 10.1111/j.1349-7006.2003.tb01402.x.
6
Phosphatidylinositol 3-kinase/Akt signaling controls endothelial cell sensitivity to Fas-mediated apoptosis via regulation of FLICE-inhibitory protein (FLIP).
Circ Res. 2001 Jul 6;89(1):13-9. doi: 10.1161/hh1301.092506.
7
Phosphatidylinositol 3-kinase/Akt activity regulates c-FLIP expression in tumor cells.
J Biol Chem. 2001 Mar 9;276(10):6893-6. doi: 10.1074/jbc.C000569200. Epub 2001 Jan 5.
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