通过调节性T细胞失调引发自身免疫。
PTENtiating autoimmunity through Treg cell deregulation.
作者信息
Ray John P, Craft Joe
机构信息
Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Department of Immunobiology and Department of Internal Medicine (Rheumatology), Yale University School of Medicine, New Haven, Connecticut, USA.
出版信息
Nat Immunol. 2015 Feb;16(2):139-40. doi: 10.1038/ni.3082.
Abstract
Regulatory T (T) cells require PTEN to block PI3K signaling while maintaining Foxp3 expression. In the absence of PTEN, T cells lose Foxp3 expression and their suppressive function, leading to a systemic increase in interferon-γ secretion, with consequent expansion of pathogenic T helper 1 and follicular B helper T cells and systemic autoimmunity.
摘要
调节性T（Treg）细胞需要PTEN来阻断PI3K信号传导，同时维持Foxp3的表达。在缺乏PTEN的情况下，T细胞失去Foxp3表达及其抑制功能，导致干扰素-γ分泌系统性增加，进而导致致病性辅助性T细胞1和滤泡辅助性T细胞扩增以及系统性自身免疫。
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