血管内皮生长因子-634G/C基因多态性与自身免疫性疾病易感性的关联：一项荟萃分析。
Association between VEGF -634G/C polymorphism and susceptibility to autoimmune diseases: a meta-analysis.
作者信息
Chen Haikui, Zhang Tianyun, Gong Bolin, Cao Xiaohong
机构信息
Department of Life Science, Beifang University of Nationalities, Yinchuan 750021, China.
The First Hospital of Chinese People's Liberation Army (PLA), Lanzhou 730050, China.
出版信息
Gene. 2015 Mar 10;558(2):181-6. doi: 10.1016/j.gene.2015.01.023. Epub 2015 Jan 14.
The role of VEGF -634G/C polymorphism has been involved in the investigations of susceptibility to autoimmune diseases, but the conclusion remains controversial. Here, we have performed a meta-analysis to clarify the relationship between them. All relevant articles updating to August 2013 were searched in PubMed and EMBASE. Crude odds ratios (ORs) with 95% confidence intervals (CIs) based on the available articles were calculated. A total of 24 independent studies associated with autoimmune disease were analyzed in our research. The results show that VEGF -634G/C polymorphism was associated with susceptibility to autoimmune disease in Asian population (C vs. G: OR=0.88, 95% CI: 0.80-0.96, P=0.543; CC vs. GG: OR=0.77, 95% CI: 0.63-0.93, P=0.787; CC+GC vs. GG: OR=0.80, 95% CI: 0.67-0.96, P=0.080 by random effects model). Nevertheless, no significant associations were found in total population or in other stratified groups. In the current meta-analysis, we reveal a significant association between VEGF -634G/C polymorphism and susceptibility to autoimmune diseases in Asian population.
血管内皮生长因子（VEGF）-634G/C多态性在自身免疫性疾病易感性研究中已有涉及，但结论仍存在争议。在此，我们进行了一项荟萃分析以阐明它们之间的关系。在PubMed和EMBASE中检索了截至2013年8月的所有相关文章。根据现有文章计算了粗比值比（OR）及其95%置信区间（CI）。我们的研究共分析了24项与自身免疫性疾病相关的独立研究。结果显示，在亚洲人群中，VEGF -634G/C多态性与自身免疫性疾病易感性相关（C vs. G：OR = 0.88，95% CI：0.80 - 0.96，P = 0.543；CC vs. GG：OR = 0.77，95% CI：0.63 - 0.93，P = 0.787；CC + GC vs. GG：采用随机效应模型时OR = 0.80，95% CI：0.67 - 0.96，P = 0.080）。然而，在总体人群或其他分层组中未发现显著关联。在当前的荟萃分析中，我们揭示了VEGF -634G/C多态性与亚洲人群自身免疫性疾病易感性之间存在显著关联。
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