分辨率革命：微观尺度下的癫痫动力学
Resolution revolution: epilepsy dynamics at the microscale.
作者信息
Szabo Gergely G, Schneider Calvin J, Soltesz Ivan
机构信息
Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.
Department of Anatomy and Neurobiology, University of California, Irvine, CA 92697, USA.
出版信息
Curr Opin Neurobiol. 2015 Apr;31:239-43. doi: 10.1016/j.conb.2014.12.012. Epub 2015 Jan 14.
Our understanding of the neuronal mechanisms behind epilepsy dynamics has recently advanced due to the application of novel technologies, monitoring hundreds of neurons with single cell resolution. These developments have provided new theories on the relationship between physiological and pathological states, as well as common motifs for the propagation of paroxysmal activity. Although traditional electroencephalogram (EEG) recordings continue to describe normal network oscillations and abnormal epileptic events within and outside of the seizure focus, analysis of epilepsy dynamics at the microscale has found variability in the composition of macroscopically repetitive epileptiform events. These novel results point to heterogeneity in the underlying dynamics of the disorder, highlighting both the need and potential for more specific and targeted therapies.
由于应用了新技术，能够以单细胞分辨率监测数百个神经元，我们对癫痫动态背后的神经元机制的理解最近有了进展。这些进展为生理状态与病理状态之间的关系提供了新理论，也为阵发性活动的传播提供了常见模式。尽管传统脑电图（EEG）记录继续描述癫痫发作灶内外的正常网络振荡和异常癫痫事件，但在微观尺度上对癫痫动态的分析发现，宏观上重复性癫痫样事件的组成存在变异性。这些新结果表明该疾病潜在动态存在异质性，突出了更具特异性和针对性疗法的必要性和潜力。
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