Crawford Andrew A, Galobardes Bruna, Jeffreys Mona, Smith George Davey, Gunnell David
School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
Psychiatry Res. 2015 Feb 28;225(3):364-7. doi: 10.1016/j.psychres.2014.12.012. Epub 2014 Dec 19.
There is emerging evidence that asthma and atopy may be associated with a higher risk of suicide. We investigated the association of asthma and atopy with mortality from suicide (n=32) in the Glasgow Alumni cohort, adjusting for the key confounders of socioeconomic position and smoking. We found no evidence of an association in our a priori atopy phenotypes with suicide, and there were insufficient suicides in the asthma phenotypes to draw any conclusions. In additional analyses, individuals reporting both eczema-urticaria and hay fever and those with family history of atopy were at higher risk of suicide. As these were secondary analyses and based on small numbers of events we cannot rule out chance findings. The lack of evidence in our main hypothesis may be due to the small number of suicides or reported associations between asthma and atopy may be confounded.
越来越多的证据表明,哮喘和特应性可能与更高的自杀风险相关。我们在格拉斯哥校友队列中调查了哮喘和特应性与自杀死亡率(n = 32)之间的关联,并对社会经济地位和吸烟等关键混杂因素进行了调整。我们没有发现先验特应性表型与自杀之间存在关联的证据,并且哮喘表型中的自杀案例数量不足,无法得出任何结论。在进一步分析中,报告患有湿疹 - 荨麻疹和花粉热的个体以及有特应性家族史的个体自杀风险更高。由于这些是二次分析且基于少量事件,我们不能排除偶然发现的可能性。我们主要假设缺乏证据可能是由于自杀案例数量较少,或者哮喘与特应性之间报告的关联可能存在混杂因素。