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治疗老年及高龄老年患者的心力衰竭。

Treating heart failure in older and oldest old patients.

作者信息

Vetrano Davide Liborio, Lattanzio Fabrizia, Martone Anna Maria, Landi Francesco, Brandi Vincenzo, Topinkova Eva, Onder Graziano

机构信息

Centro Medicina dell'Invecchiamento, Dipartimento di Scienze Gerontologiche, Geriatriche e Fisiatriche, Università Cattolica del Sacro Cuore, Largo F. Vito 1, 00168, Roma, Italy.

出版信息

Curr Pharm Des. 2015;21(13):1659-64. doi: 10.2174/1381612821666150130124021.

Abstract

Advanced age is a relevant risk factor for the heart failure (HF). The development of new pharmacological and non-pharmacological approaches has determined an improvement in survival of patients with HF, leading to the selection of an older and frailer population with HF. The clinical approach to such a complex population should require clear indications to assist physicians during their daily practice, but there is a huge lack of evidence regarding the treatment of HF in the oldest among the elderly patient population. In addition, the co-occurrence of specific conditions that are extremely prevalent in older individuals with HF, such as cognitive impairment, comorbidities, and polypharmacy, can further complicate the clinical man agement of this condition. Thus, a multidisciplinary approach with the goal of recognizing and treating conditions associated with HF may be necessary to improve the quality of care and to reduce expenditures. Several studies have assessed the effect of a comprehensive geriatric assessment and management on quality of care in HF patients, demonstrating a substantial improvement in patient outcomes and administration of the appropriate drug treatment.

摘要

高龄是心力衰竭(HF)的一个相关风险因素。新的药物和非药物治疗方法的发展已使HF患者的生存率得到改善,导致HF患者群体老龄化且更加虚弱。对于这样一个复杂群体的临床治疗方法应需要明确的指征,以在医生的日常实践中提供帮助,但在老年患者群体中最年长者的HF治疗方面存在大量证据不足的情况。此外,在患有HF的老年人中极为普遍的特定情况,如认知障碍、合并症和多重用药的同时出现,会使这种疾病的临床管理进一步复杂化。因此,可能需要一种以识别和治疗与HF相关病症为目标的多学科方法,以提高护理质量并减少开支。多项研究评估了全面的老年医学评估和管理对HF患者护理质量的影响,表明患者结局和适当药物治疗的管理有显著改善。

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