通过烯二酮与芳基氯直接芳基化反应合成高取代吡唑类化合物。
Direct arylation of sydnones with aryl chlorides toward highly substituted pyrazoles.
作者信息
Brown Andrew W, Harrity Joseph P A
机构信息
Department of Chemistry, University of Sheffield , Brook Hill, S3 7HF, U.K.
出版信息
J Org Chem. 2015 Feb 20;80(4):2467-72. doi: 10.1021/acs.joc.5b00143. Epub 2015 Feb 6.
PMID:25635522
Abstract
The direct arylation of the C4 position of both N-alkyl- and N-arylsydnones with aryl/heteroaryl chlorides has been realized. The reaction is quite general and allows access to a wide range of 4-substituted sydnones. Yields of more challenging substrates can be improved through the use of aryl bromides.
摘要
实现了N-烷基和N-芳基斯德酮的C4位与芳基/杂芳基氯化物的直接芳基化反应。该反应具有广泛的适用性，可用于制备多种4-取代斯德酮。对于更具挑战性的底物，通过使用芳基溴化物可以提高产率。
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