诺索霉素的体外和体内抗耐甲氧西林金黄色葡萄球菌活性
In vitro and in vivo anti-MRSA activities of nosokomycins.
作者信息
Uchida Ryuji, Hanaki Hideaki, Matsui Hidenori, Hamamoto Hiroshi, Sekimizu Kazuhisa, Iwatsuki Masato, Kim Yong Pil, Tomoda Hiroshi
机构信息
Graduate School of Pharmaceutical Sciences, Kitasato University.
出版信息
Drug Discov Ther. 2014 Dec;8(6):249-54. doi: 10.5582/ddt.2014.01050.
The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model.
研究了在蚕-耐甲氧西林金黄色葡萄球菌（MRSA）感染筛选中发现的诺索霉素A至D对MRSA的活性。计算出诺索霉素对标准MRSA和金黄色葡萄球菌菌株的最低抑菌浓度（MIC）值为0.06至2.0μg/mL。它们对54株临床分离的MRSA菌株也显示出强效抑制活性。此外，诺索霉素A在小鼠MRSA感染模型中被证明是有效的。
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