角鲨烯如何通过携带抗原的中性粒细胞和白细胞介素-18来助力产生抗原特异性T细胞。
How squalene GLAdly helps generate antigen-specific T cells via antigen-carrying neutrophils and IL-18.
作者信息
Kedl Justin D, Kedl Ross M
机构信息
Department of Immunology and Microbiology, School of Medicine, University of Colorado Denver, Aurora, CO, USA.
出版信息
Eur J Immunol. 2015 Feb;45(2):376-9. doi: 10.1002/eji.201445379.
Abstract
The mechanisms by which squalene, which in oil-and-water emulsions has been shown to be an excellent formulation for TLR agonists, enhances the magnitude and quality of adaptive immune responses are not thoroughly defined. In this issue of the European Journal of Immunology [Eur. J. Immunol. 2015. 45: 407-417], Desbien et al. show that a squalene/TLR4-based adjuvant augments antigen-specific Th1 responses in vaccinated mice through a caspase/IL-18-dependent mechanism. This commentary will discuss the authors' findings in the context of elucidating the mechanism of action of squalene as an adjuvant, and the new questions that the work generates.
摘要
在油包水乳液中，角鲨烯已被证明是TLR激动剂的一种极佳配方，但其增强适应性免疫反应的强度和质量的机制尚未完全明确。在本期《欧洲免疫学杂志》[《欧洲免疫学杂志》2015年。45: 407 - 417]中，德斯比恩等人表明，基于角鲨烯/TLR4的佐剂通过一种半胱天冬酶/IL - 18依赖机制增强接种疫苗小鼠的抗原特异性Th1反应。本评论将在阐明角鲨烯作为佐剂的作用机制的背景下讨论作者的发现，以及该研究产生的新问题。
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2
T cell responses: naive to memory and everything in between.
Adv Physiol Educ. 2013 Dec;37(4):273-83. doi: 10.1152/advan.00066.2013.
3
AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC.
Cell Death Differ. 2013 Sep;20(9):1149-60. doi: 10.1038/cdd.2013.37. Epub 2013 May 3.
4
Persistent antigen at vaccination sites induces tumor-specific CD8⁺ T cell sequestration, dysfunction and deletion.
Nat Med. 2013 Apr;19(4):465-72. doi: 10.1038/nm.3105. Epub 2013 Mar 3.
5
Host DNA released in response to aluminum adjuvant enhances MHC class II-mediated antigen presentation and prolongs CD4 T-cell interactions with dendritic cells.
Proc Natl Acad Sci U S A. 2013 Mar 19;110(12):E1122-31. doi: 10.1073/pnas.1300392110. Epub 2013 Feb 27.
6
The mechanism of action of MF59 - an innately attractive adjuvant formulation.
Vaccine. 2012 Jun 19;30(29):4341-8. doi: 10.1016/j.vaccine.2011.09.061.
7
Adjuvanticity of the oil-in-water emulsion MF59 is independent of Nlrp3 inflammasome but requires the adaptor protein MyD88.
Proc Natl Acad Sci U S A. 2011 Jul 5;108(27):11169-74. doi: 10.1073/pnas.1107941108. Epub 2011 Jun 20.
8
Programming the magnitude and persistence of antibody responses with innate immunity.
Nature. 2011 Feb 24;470(7335):543-7. doi: 10.1038/nature09737.
9
Inflammasome-independent role of the apoptosis-associated speck-like protein containing CARD (ASC) in the adjuvant effect of MF59.
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2927-32. doi: 10.1073/pnas.1012455108. Epub 2011 Jan 26.
10
Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes.
Vaccine. 2011 Feb 17;29(9):1812-23. doi: 10.1016/j.vaccine.2010.12.090. Epub 2011 Jan 6.
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