使用高价碘试剂对杂环化合物进行炔基化反应。
Alkynylation of heterocyclic compounds using hypervalent iodine reagent.
作者信息
Kamlar M, Císařová I, Veselý J
机构信息
Department of Organic Chemistry, Faculty of Science, Charles University in Prague, Hlavova 2030, 128 43, Praha 2, Czech Republic.
出版信息
Org Biomol Chem. 2015 Mar 14;13(10):2884-9. doi: 10.1039/c4ob02625j.
PMID:25642993
Abstract
The alkynylation of various nitrogen- and/or sulphur-containing heterocyclic compounds using hypervalent iodine TMS-EBX by utilization of tertiary amines under mild conditions is described. The developed metal-free methodology furnishes the corresponding alkynylated heterocycles bearing quaternary carbon in high yields.
摘要
描述了在温和条件下利用叔胺，使用高价碘TMS-EBX对各种含氮和/或含硫杂环化合物进行炔基化反应。所开发的无金属方法能以高产率提供带有季碳的相应炔基化杂环化合物。
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